Difference between revisions of "Part:BBa K2520040"

 
 
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<partinfo>BBa_K2520040 short</partinfo>
 
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Third common epitope of multiple sclerosis.
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===Introduction===
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In MS, the immune system attacks the protective sheath (myelin) that covers nerve fibers and causes communication problems between your brain and the rest of your body. Eventually, the disease can cause the nerves themselves to deteriorate or become permanently damaged.
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In MS disease, T cells attack 3 types of glycoprotein:
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1) Myelin basic protein (MBP)
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2) Proteolipid protein (PLP)
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3) myelin oligodendrocyte
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glycoprotein (MOG)
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===Experimental  autoimmune encephalomyelitis (EAE)===
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EAE is a CD4' T cell-mediated inflammatory disease of the central nervous  system  (CNS)  induced  in  experimental  animals with CNS homogenate, myelin or myelin components. In its  chronic  form,  EAE is a well  accepted  experimental model  for  multiple sclerosis (MS).
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===Epitopes===
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MOG glycoprotein is the only CNS autoantigen known to induce both a T-cell response and a demyelinating autoantibody response in EAE
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Therefore, we chose the three epitopes that induced the most significant immune response.
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MOG3 is the third epitope that appears in the MOG glycoprotein sequence (304-337)
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===References===
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Mendel, Itzhack, Nicole Kerlero de Rosbo, and Avraham Ben‐Nun. "A myelin oligodendrocyte glycoprotein peptide induces typical chronic experimental autoimmune encephalomyelitis in H‐2b mice: Fine specificity and T cell receptor Vβ expression of encephalitogenic T cells." European journal of immunology 25.7 (1995): 1951-1959.‏
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APA
  
 
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===Functional Parameters===
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<partinfo>BBa_K2520040 parameters</partinfo>
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Latest revision as of 11:57, 31 October 2017

MOG 3

Introduction

In MS, the immune system attacks the protective sheath (myelin) that covers nerve fibers and causes communication problems between your brain and the rest of your body. Eventually, the disease can cause the nerves themselves to deteriorate or become permanently damaged.

In MS disease, T cells attack 3 types of glycoprotein:

1) Myelin basic protein (MBP)

2) Proteolipid protein (PLP)

3) myelin oligodendrocyte glycoprotein (MOG)

Experimental autoimmune encephalomyelitis (EAE)

EAE is a CD4' T cell-mediated inflammatory disease of the central nervous system (CNS) induced in experimental animals with CNS homogenate, myelin or myelin components. In its chronic form, EAE is a well accepted experimental model for multiple sclerosis (MS).

Epitopes

MOG glycoprotein is the only CNS autoantigen known to induce both a T-cell response and a demyelinating autoantibody response in EAE

Therefore, we chose the three epitopes that induced the most significant immune response.

MOG3 is the third epitope that appears in the MOG glycoprotein sequence (304-337)

References

Mendel, Itzhack, Nicole Kerlero de Rosbo, and Avraham Ben‐Nun. "A myelin oligodendrocyte glycoprotein peptide induces typical chronic experimental autoimmune encephalomyelitis in H‐2b mice: Fine specificity and T cell receptor Vβ expression of encephalitogenic T cells." European journal of immunology 25.7 (1995): 1951-1959.‏ APA

Sequence and Features


Assembly Compatibility:
  • 10
    COMPATIBLE WITH RFC[10]
  • 12
    COMPATIBLE WITH RFC[12]
  • 21
    COMPATIBLE WITH RFC[21]
  • 23
    COMPATIBLE WITH RFC[23]
  • 25
    COMPATIBLE WITH RFC[25]
  • 1000
    COMPATIBLE WITH RFC[1000]