Difference between revisions of "Part:BBa I712020"

 
 
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Homo sapiens caspase 3, apoptosis-related cysteine peptidase (transcript variant beta).
 
Homo sapiens caspase 3, apoptosis-related cysteine peptidase (transcript variant beta).
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===Information contributed by City of London UK (2021)===
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Part information is collated here to help future users of the BioBrick registry.
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Metadata:
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Group: City of London UK 2021
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Author: Julian Chen
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Summary: Added information collated from existing scientific studies
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Part is involved in the activation cascade of caspases contributing to apoptosis.
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At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond
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Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9.
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The part is also involved in the cleavage of Huntingtin (HTT gene). <ref>“CASP3 - Caspase-3 Precursor - Homo Sapiens (Human) - CASP3 Gene & Protein.” 2021. Uniprot.org. 2021. https://www.uniprot.org/uniprot/P42574.
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‌</ref>
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===Activity Regulation===
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Part is inhibited via isatin sulfonamides
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<!-- Add more about the biology of this part here
 
<!-- Add more about the biology of this part here

Latest revision as of 17:40, 1 October 2021


Homo sapiens caspase 3

Homo sapiens caspase 3, apoptosis-related cysteine peptidase (transcript variant beta).

Information contributed by City of London UK (2021)

Part information is collated here to help future users of the BioBrick registry.

Metadata:

Group: City of London UK 2021

Author: Julian Chen

Summary: Added information collated from existing scientific studies


Part is involved in the activation cascade of caspases contributing to apoptosis. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. The part is also involved in the cleavage of Huntingtin (HTT gene). [1]


Activity Regulation

Part is inhibited via isatin sulfonamides



Sequence and Features


Assembly Compatibility:
  • 10
    COMPATIBLE WITH RFC[10]
  • 12
    COMPATIBLE WITH RFC[12]
  • 21
    COMPATIBLE WITH RFC[21]
  • 23
    COMPATIBLE WITH RFC[23]
  • 25
    COMPATIBLE WITH RFC[25]
  • 1000
    COMPATIBLE WITH RFC[1000]


  1. ↑ “CASP3 - Caspase-3 Precursor - Homo Sapiens (Human) - CASP3 Gene & Protein.” 2021. Uniprot.org. 2021. https://www.uniprot.org/uniprot/P42574. ‌