Difference between revisions of "Part:BBa K2309025"
 
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Grammistin-Pp1 is an antimicrobial peptide secreted by soapfish with 13-residue long. This peptide is secreted to protect the fish themselves from pathogenic implantation and/or to kill pathogenic microbes. According to the research, this peptide can inhibit the growth of Gram-positive and Gram-negative bacteria at µM levels because of the interaction between membrane phospholipids and Grammistin-Pp1. The Grammistin-Pp1 has alpha helix structure, which contains positive charge. We pick it because this peptide shown to be lethal against S. aureus.
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Grammistins are a group of peptides secreted by soapfishes and characterized by its amphiphilic -helical structure. There are four types of Grammistins: Pp1,Pp3, Gs1, and Gs2. Gs 1 and Gs 2 are from Grammistes sexlineatus and Pp 1 and Pp 3 from Pogonoperca punctata (Yokota, Nagashima, and Shiom, 2001). Grammistin-Pp1 is made up of thirteen amino acid residues. Studies showed that Grammistin-Pp1 could interact with phospholipids and influence the permeability of membrane. Sugiyama et al. (2006) reported that the peptide Grammistin-Pp1 is effective on both Gram negative bacteria and Gram positive bacteria, which includes Staphylococcus aureus.

Latest revision as of 08:28, 1 November 2017

Grammistins are a group of peptides secreted by soapfishes and characterized by its amphiphilic -helical structure. There are four types of Grammistins: Pp1,Pp3, Gs1, and Gs2. Gs 1 and Gs 2 are from Grammistes sexlineatus and Pp 1 and Pp 3 from Pogonoperca punctata (Yokota, Nagashima, and Shiom, 2001). Grammistin-Pp1 is made up of thirteen amino acid residues. Studies showed that Grammistin-Pp1 could interact with phospholipids and influence the permeability of membrane. Sugiyama et al. (2006) reported that the peptide Grammistin-Pp1 is effective on both Gram negative bacteria and Gram positive bacteria, which includes Staphylococcus aureus.