Difference between revisions of "Part:BBa K2309023"

Latest revision as of 09:49, 1 November 2017

GF-17--The major antimicrobial region of LL-37 for Lactococcus lactis NZ9000

Human cathelicidin LL-37, which contains amphipathic molecules for bacterial killing, is an essential component of the innate immune system. By appending a glycine at the N-terminus of FK-16, the linear cationic amphipathic peptide. GF-17 is a highly efficient anti-microbial peptide derived from the residure Phe-17 to Val-32 of LL-37. GF-17 was very efficient in eliminating both Gram-positive and Gram-negative bacteria, such as S. aureus USA300 and E. coli K-12in vitro. Additionally, to compare with LL-37, GF-17 is highly efficient in inhibition of biofilm formation and killing efficiency on Staphylococcus aureus.

Sequence and Features

Assembly Compatibility:

10
COMPATIBLE WITH RFC[10]
12
COMPATIBLE WITH RFC[12]
21
COMPATIBLE WITH RFC[21]
23
COMPATIBLE WITH RFC[23]
25
COMPATIBLE WITH RFC[25]
1000
COMPATIBLE WITH RFC[1000]

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 <partinfo>BBa_K2309023 short</partinfo>
-Human cathelicidin LL-37, which contains amphipathic molecules for bacterial killing, is an essential component of the innate immune system. By appending a glycine at the N-terminus of FK-16, the linear cationic amphipathic peptide, GF-17, are more important in bacterial membrane permeation, but less toxic to human cells sheds new light on controlling invading pathogens.
+Human cathelicidin LL-37, which contains amphipathic molecules for bacterial killing, is an essential component of the innate immune system. By appending a glycine at the N-terminus of FK-16, the linear cationic amphipathic peptide.
+GF-17 is a highly efficient anti-microbial peptide derived from the residure Phe-17 to Val-32 of LL-37. GF-17 was very efficient in eliminating both Gram-positive and Gram-negative bacteria, such as S. aureus USA300 and E. coli K-12in vitro. Additionally, to compare with LL-37, GF-17 is highly efficient in inhibition of biofilm formation and killing efficiency on Staphylococcus aureus.
 <!-- Add more about the biology of this part here