Difference between revisions of "Part:BBa J100176"
 
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<partinfo>BBa_J100176 short</partinfo>
 
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FabHAF is a bacterial transcription factor from Bacillus subtilis that regulates gene expression related to fatty acids and phospholipid metabolism. It can be used for sensing the fatty acid biosynthesis status and adjusting fap regulon expression.  
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FabHAF is an operon of Bacillus subtilis that "codes for the FAbHA and FabF condensing enzymes" (663), which are responsible for the elongation of fatty acid in the bacterial membrane. The transcription factor FapR upregulates fabHAF in response to fatty acid deprivation, which occurs in presence of "inhibitors of fatty acid synthesis such as cerulenin and triclosan" (665).
  
 
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Latest revision as of 01:07, 15 October 2014

FabHAF promoter

FabHAF is an operon of Bacillus subtilis that "codes for the FAbHA and FabF condensing enzymes" (663), which are responsible for the elongation of fatty acid in the bacterial membrane. The transcription factor FapR upregulates fabHAF in response to fatty acid deprivation, which occurs in presence of "inhibitors of fatty acid synthesis such as cerulenin and triclosan" (665).

Source: Schujman, Gustavo E., Luciana Paoletti, Alan D. Grossman, and Diego De Mendoza. "FapR, a Bacterial Transcription Factor Involved in Global Regulation of Membrane Lipid Biosynthesis." Developmental Cell (2003): 663-72. National Center for Biotechnology Information. Web. 11 Sept. 2014. <http://www.ncbi.nlm.nih.gov/pubmed/12737802>.

Sequence and Features


Assembly Compatibility:
  • 10
    COMPATIBLE WITH RFC[10]
  • 12
    COMPATIBLE WITH RFC[12]
  • 21
    COMPATIBLE WITH RFC[21]
  • 23
    COMPATIBLE WITH RFC[23]
  • 25
    COMPATIBLE WITH RFC[25]
  • 1000
    COMPATIBLE WITH RFC[1000]