Difference between revisions of "Part:BBa K1119002"
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<partinfo>BBa_K1119002 short</partinfo> | <partinfo>BBa_K1119002 short</partinfo> | ||
| − | aceA codes for isocitrate lyase, native in E. coli strain BW25113. | + | <i>aceA</i> codes for isocitrate lyase, native in <i>E. coli</i> K-12 strain BW25113. This part is useful for regulating metabolic pathway. This is enzyme involved in the glyoxylate cycle in plants and bacteria. The glyoxylate enzyme allows plants and bacteria to use fatty acids as a substrate for gluconeogenesis and avoid complete oxiation into carbon dioxide. HKUST 2013 team has introduced this prokaryotic gene into mammalian cell to create an artificial futile cycle that increases uptake of fatty acids in the medium. |
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===Usage and Biology=== | ===Usage and Biology=== | ||
Latest revision as of 15:28, 27 September 2013
aceA
aceA codes for isocitrate lyase, native in E. coli K-12 strain BW25113. This part is useful for regulating metabolic pathway. This is enzyme involved in the glyoxylate cycle in plants and bacteria. The glyoxylate enzyme allows plants and bacteria to use fatty acids as a substrate for gluconeogenesis and avoid complete oxiation into carbon dioxide. HKUST 2013 team has introduced this prokaryotic gene into mammalian cell to create an artificial futile cycle that increases uptake of fatty acids in the medium.
Sequence and Features
Assembly Compatibility:
- 10COMPATIBLE WITH RFC[10]
- 12COMPATIBLE WITH RFC[12]
- 21COMPATIBLE WITH RFC[21]
- 23COMPATIBLE WITH RFC[23]
- 25COMPATIBLE WITH RFC[25]
- 1000COMPATIBLE WITH RFC[1000]