Difference between revisions of "Part:BBa K847003"

Latest revision as of 02:48, 4 October 2012

''Deinococcus radiodurans'' Superoxide dismutase, SodMn

Deinococcus radiodurans is an extremely radiation-resistant bacterium: while about 10 Gy (absorbed radiation dose, Gray) can kill most vertebrates, D. radiodurans can withstand up to 12,000 Gy. Current literature supports this finding with D. radiodurans’ unique genetic makeup which allows it to better handle radiation exposure. The two main effects of radiation exposure to bacterial cells are DNA damage and the creation of toxic superoxide species (Daly 2009). To take care of the pesky superoxides, superoxide dismutases are expressed in high levels in D. radiodurans (Slade and Miroslav 2011). These enzymes break the reactive species down into harmless oxygen and hydrogen peroxides. This dismutase uses manganese as a cofactor (Gao, Zhang, Song, Chen, and Zhong 2009).

Sequence and Features

Assembly Compatibility:

10
INCOMPATIBLE WITH RFC[10]
Illegal EcoRI site found at 139
12
INCOMPATIBLE WITH RFC[12]
Illegal EcoRI site found at 139
21
INCOMPATIBLE WITH RFC[21]
Illegal EcoRI site found at 139
23
INCOMPATIBLE WITH RFC[23]
Illegal EcoRI site found at 139
25
INCOMPATIBLE WITH RFC[25]
Illegal EcoRI site found at 139
1000
COMPATIBLE WITH RFC[1000]

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 __NOTOC__
 <partinfo>BBa_K847003 short</partinfo>
-tba
-<!-- Add more about the biology of this part here
+''Deinococcus radiodurans'' is an extremely radiation-resistant bacterium: while about 10 Gy (absorbed radiation dose, Gray) can kill most vertebrates, ''D. radiodurans'' can withstand up to 12,000 Gy. Current literature supports this finding with ''D. radiodurans’'' unique genetic makeup which allows it to better handle radiation exposure. The two main effects of radiation exposure to bacterial cells are DNA damage and the creation of toxic superoxide species (Daly 2009). To take care of the pesky superoxides, superoxide dismutases are expressed in high levels in ''D. radiodurans'' (Slade and Miroslav 2011). These enzymes break the reactive species down into harmless oxygen and hydrogen peroxides. This dismutase uses manganese as a cofactor (Gao, Zhang, Song, Chen, and Zhong 2009).
-===Usage and Biology===
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