Difference between revisions of "Part:BBa K727007"

Latest revision as of 20:28, 27 October 2020

Rose Odor Generator Device (Geraniol)

This part is assembled with geranyl diphosphate synthase (BBa_K727005[1]) and geraniol synthase (BBa_K727006[2]).

Geraniol is a monoterpenoid and an alcohol. It’s molecular formula is C10H18O . It is the primary part of rose oil, palmarosa oil, and citronella oil (Java type). It also occurs in small quantities in geranium, lemon, and many other essential oils.

It has a rose-like odor and is commonly used in perfumes. It is used in flavors such as peach, raspberry, grapefruit, red apple, plum, lime, orange, lemon, watermelon, pineapple, and blueberry.

Lethbridge_HS Contribution 2020: Research Update

Apart from being a component in rose and other aromatic oils, Geraniol has many pharmacological properties. According to a study using a streptozotocin induced diabetic model in rats, the administration of GE for a period of 45 days was seen to have decreased the levels of hemoglobin HbA1C and plasma glucose; this resulted in a restoration of glucose homeostasis [1]. Geraniol is also seen to alleviate other diabetes based health problems, such as having a protective effect on diabetic neuropathy [2], attenuating diabetes-induced cardiac functional disorder [3], and improving heightened vasoconstriction caused by diabetes [4]. In general, Geraniol has been seen to have a plethora of pharmacological benefits, and is believed, due to mounting evidence in the last several decades, to be a botanical compound that does not have any harmful effects [5].

Additionally, studies of the compound demonstrate fungicidal and antilarval properties, suggesting GE’s potential in the biocide industry. The antifungal effects of geraniol may be due to the ability of this monoterpene to travel across the cell membranes of phytopathogenic fungi and, in doing so, interacting with various membrane proteins. This interaction can result in the hyphae, an aspect of the fungi’s mycelium [6] and the plasma membrane. [7] Despite these considerable benefits of GE, it is seen to have low economic value, as it can only be extracted at very low concentrations from plants [8]. Most microorganisms, with the exception of some Saccharomyces cerevisiae strains [9], are unable to synthesize monoterpenes, and cannot synthesize GE naturally, due to the lack of a geranyl diphosphate synthase (GPPS). However, a 2016 paper [8] attempted to increase the yield of geraniol production, by engineering E.coli and utilizing the biotransformation from geraniol acetate to geraniol.

Sequence and Features