Difference between revisions of "Part:BBa K364307"
 
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More on ER here: [http://en.wikipedia.org/wiki/RXRA].
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More on ER here: [http://en.wikipedia.org/wiki/Estrogen_receptor].
  
 
ER Uniprot: [http://www.uniprot.org/uniprot/P03372].
 
ER Uniprot: [http://www.uniprot.org/uniprot/P03372].

Latest revision as of 19:56, 26 October 2010

Human ER DBD

Estrogen receptor refers to a group of receptors that are activated by the hormone 17β-estradiol (estrogen) , which is a member of the nuclear hormone family of intracellular receptors. The main function of the estrogen receptor is as a DNA-binding transcription factor that regulates gene expression. It has a variety of central physiological roles, including those involved in maintenance of the reproductive, cardiovascular, musculoskeletal and central nervous systems.


More on ER here: [http://en.wikipedia.org/wiki/Estrogen_receptor].

ER Uniprot: [http://www.uniprot.org/uniprot/P03372].

View the ER DBD crystal structure here: [http://www.pdb.org/pdb/explore/jmol.do?structureId=1HCQ&bionumber=1].

Picture of human ER DNA binding domain.

Description of the ER DBD crystal structure with reference here: [http://www.cell.com/retrieve/pii/009286749390390C].

Picture of gel electrophoresis: ER DBD in pSB1C3 resulting an insert of 318 bp.


Sequence and Features


Assembly Compatibility:
  • 10
    INCOMPATIBLE WITH RFC[10]
    Unknown
  • 12
    INCOMPATIBLE WITH RFC[12]
    Unknown
  • 21
    INCOMPATIBLE WITH RFC[21]
    Unknown
  • 23
    INCOMPATIBLE WITH RFC[23]
    Unknown
  • 25
    INCOMPATIBLE WITH RFC[25]
    Unknown
  • 1000
    COMPATIBLE WITH RFC[1000]