Difference between revisions of "Part:BBa K364307"
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− | Estrogen receptor refers to a group of receptors that are activated by the hormone 17β-estradiol | + | Estrogen receptor refers to a group of receptors that are activated by the hormone 17β-estradiol (estrogen) , which is a member of the nuclear hormone family of intracellular receptors. The main function of the estrogen receptor is as a DNA-binding transcription factor that regulates gene expression. It has a variety of central physiological roles, including those involved in maintenance of the reproductive, cardiovascular, musculoskeletal and central nervous systems. |
− | The main function of the estrogen receptor is as a DNA-binding transcription factor that regulates gene expression. | + | |
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+ | More on ER here: [http://en.wikipedia.org/wiki/Estrogen_receptor]. | ||
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+ | ER Uniprot: [http://www.uniprot.org/uniprot/P03372]. | ||
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+ | View the ER DBD crystal structure here: [http://www.pdb.org/pdb/explore/jmol.do?structureId=1HCQ&bionumber=1]. | ||
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+ | [[Image:ER-DBD.jpg|800px|thumb|center|Picture of human ER DNA binding domain.]] | ||
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+ | Description of the ER DBD crystal structure with reference here: [http://www.cell.com/retrieve/pii/009286749390390C]. | ||
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+ | [[Image:ERdbd.jpg|800px|thumb|center|Picture of gel electrophoresis: ER DBD in pSB1C3 resulting an insert of 318 bp.]] | ||
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Latest revision as of 19:56, 26 October 2010
Human ER DBD
Estrogen receptor refers to a group of receptors that are activated by the hormone 17β-estradiol (estrogen) , which is a member of the nuclear hormone family of intracellular receptors. The main function of the estrogen receptor is as a DNA-binding transcription factor that regulates gene expression. It has a variety of central physiological roles, including those involved in maintenance of the reproductive, cardiovascular, musculoskeletal and central nervous systems.
More on ER here: [http://en.wikipedia.org/wiki/Estrogen_receptor].
ER Uniprot: [http://www.uniprot.org/uniprot/P03372].
View the ER DBD crystal structure here: [http://www.pdb.org/pdb/explore/jmol.do?structureId=1HCQ&bionumber=1].
Description of the ER DBD crystal structure with reference here: [http://www.cell.com/retrieve/pii/009286749390390C].
Sequence and Features
- 10COMPATIBLE WITH RFC[10]
- 12COMPATIBLE WITH RFC[12]
- 21COMPATIBLE WITH RFC[21]
- 23COMPATIBLE WITH RFC[23]
- 25COMPATIBLE WITH RFC[25]
- 1000COMPATIBLE WITH RFC[1000]