Difference between revisions of "Part:BBa K364310"
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The ecdysone receptor is a nuclear receptor found in arthropods, where it controls development and contributes to other processes such as reproduction. | The ecdysone receptor is a nuclear receptor found in arthropods, where it controls development and contributes to other processes such as reproduction. | ||
The receptor is a non-covalent heterodimer of two proteins, the EcR protein and ultraspiracle protein (USP). It binds to and is activated by ecdysteroids. | The receptor is a non-covalent heterodimer of two proteins, the EcR protein and ultraspiracle protein (USP). It binds to and is activated by ecdysteroids. | ||
| − | Pulses of 20-hydroxyecdysone occur during insect development, whereupon this hormone binds to the ecdysone receptor, a ligand-activated transcription factor found in the nuclei of insect cells. This in turn leads to the activation of many other genes,which ultimately causes physiological changes that result in ecdysis (moulting). | + | Pulses of 20-hydroxyecdysone occur during insect development, whereupon this hormone binds to the ecdysone receptor, a ligand-activated transcription factor found in the nuclei of insect cells. This in turn leads to the activation of many other genes, which ultimately causes physiological changes that result in ecdysis (moulting). |
| − | [[Image:Ecr Usp heterodimer.jpg]] | + | More on Ecdysone receptor here: [http://en.wikipedia.org/wiki/Ecdysone_receptor]. |
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| + | Ecdysone receptor Uniprot: [http://www.uniprot.org/uniprot/P34021]. | ||
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| + | View the Ecdysone receptor crystal structure here: [http://www.rcsb.org/pdb/explore/jmol.do?structureId=1R1K&bionumber=1]. | ||
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| + | [[Image:Ecr-Usp heterodimer.jpg|800px|thumb|center|Picture of Ecdysone receptor USP (Ultraspiracle) heterodimer. Ponasterone A a specific agonist bound to the Ecdysone receptor ligand binding domain.]] | ||
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| + | Description of the RXRa DBD crystal structure with reference here: [http://www.nature.com/nature/journal/v426/n6962/full/nature02112.html]. | ||
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| + | [[Image:ecrLBD.jpg|800px|thumb|center|Picture of gel electrophoresis: EcR LBD in pSB1C3 results a 768 bp long insert]] | ||
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Latest revision as of 19:37, 26 October 2010
EcR LBD
The ecdysone receptor is a nuclear receptor found in arthropods, where it controls development and contributes to other processes such as reproduction. The receptor is a non-covalent heterodimer of two proteins, the EcR protein and ultraspiracle protein (USP). It binds to and is activated by ecdysteroids. Pulses of 20-hydroxyecdysone occur during insect development, whereupon this hormone binds to the ecdysone receptor, a ligand-activated transcription factor found in the nuclei of insect cells. This in turn leads to the activation of many other genes, which ultimately causes physiological changes that result in ecdysis (moulting).
More on Ecdysone receptor here: [http://en.wikipedia.org/wiki/Ecdysone_receptor].
Ecdysone receptor Uniprot: [http://www.uniprot.org/uniprot/P34021].
View the Ecdysone receptor crystal structure here: [http://www.rcsb.org/pdb/explore/jmol.do?structureId=1R1K&bionumber=1].
Description of the RXRa DBD crystal structure with reference here: [http://www.nature.com/nature/journal/v426/n6962/full/nature02112.html].
Sequence and Features
- 10COMPATIBLE WITH RFC[10]
- 12COMPATIBLE WITH RFC[12]
- 21INCOMPATIBLE WITH RFC[21]Illegal BglII site found at 683
- 23COMPATIBLE WITH RFC[23]
- 25COMPATIBLE WITH RFC[25]
- 1000COMPATIBLE WITH RFC[1000]