Difference between revisions of "Part:BBa K364310:Experience"
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This experience page is provided so that any user may enter their experience using this part.<BR>Please enter | This experience page is provided so that any user may enter their experience using this part.<BR>Please enter | ||
how you used this part and how it worked out. | how you used this part and how it worked out. | ||
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| + | ===Ligand=== | ||
| + | |||
| + | Ecdysteroids (EcR) | ||
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| + | Ecdysteroids are insect moulting and sex hormones which include ecdysone and | ||
| + | its homologues such as 20-hydroxyecdysone. Ecdysteroids also occur in other | ||
| + | invertebrates where they can play a different role. They also appear in many plants | ||
| + | mostly as a protection agents (toxins or antifeedants) against herbivore insects. | ||
| + | These phytoecdysteroids have medicinal value and are part of herbal adaptogenic | ||
| + | remedies like cordyceps. | ||
===Physiological effects of EcR=== | ===Physiological effects of EcR=== | ||
Revision as of 01:06, 26 October 2010
This experience page is provided so that any user may enter their experience using this part.
Please enter
how you used this part and how it worked out.
Ligand
Ecdysteroids (EcR)
Ecdysteroids are insect moulting and sex hormones which include ecdysone and its homologues such as 20-hydroxyecdysone. Ecdysteroids also occur in other invertebrates where they can play a different role. They also appear in many plants mostly as a protection agents (toxins or antifeedants) against herbivore insects. These phytoecdysteroids have medicinal value and are part of herbal adaptogenic remedies like cordyceps.
Physiological effects of EcR
Pulses of 20-hydroxyecdysone occur during insect development, whereupon this hormone binds to the ecdysone receptor, a ligand-activated transcription factor found in the nuclei of insect cells. This in turn leads to the activation of many other genes, as evidenced by chromosomal puffing at over a hundred sites. Ultimately the activation cascade causes physiological changes that result in ecdysis (moulting).
Potential applications of EcR LBD
EcR LBD can be fused with different DBDs in order to activate downstream gene expression depending on the binding site of the DBD.
Applications of BBa_K364310
User Reviews
UNIQda41450da2b379e3-partinfo-00000000-QINU UNIQda41450da2b379e3-partinfo-00000001-QINU