Difference between revisions of "Part:BBa K364307"

Revision as of 20:27, 25 October 2010

Human ER DBD

Estrogen receptor refers to a group of receptors that are activated by the hormone 17β-estradiol (estrogen) , which is a member of the nuclear hormone family of intracellular receptors. The main function of the estrogen receptor is as a DNA-binding transcription factor that regulates gene expression. It has a variety of central physiological roles, including those involved in maintenance of the reproductive, cardiovascular, musculoskeletal and central nervous systems.

More on ER here: [http://en.wikipedia.org/wiki/RXRA].

ER Uniprot: [http://www.uniprot.org/uniprot/P03372].

View the ER DBD crystal structure here: [http://www.pdb.org/pdb/explore/jmol.do?structureId=1HCQ&bionumber=1].

Picture of human ER DNA binding domain.

Description of the ER DBD crystal structure with reference here: [http://www.cell.com/retrieve/pii/009286749390390C].

Sequence and Features

Assembly Compatibility:

10
INCOMPATIBLE WITH RFC[10]
Unknown
12
COMPATIBLE WITH RFC[12]
21
INCOMPATIBLE WITH RFC[21]
Unknown
23
INCOMPATIBLE WITH RFC[23]
Unknown
25
COMPATIBLE WITH RFC[25]
1000
COMPATIBLE WITH RFC[1000]

@@ Line 2: / Line 2: @@
 <partinfo>BBa_K364307 short</partinfo>
-Estrogen receptor refers to a group of receptors that are activated by the hormone 17&#946;-estradiol[1] (estrogen) , which is a member of the nuclear hormone family of intracellular receptors.
+Estrogen receptor refers to a group of receptors that are activated by the hormone 17&#946;-estradiol (estrogen) , which is a member of the nuclear hormone family of intracellular receptors. The main function of the estrogen receptor is as a DNA-binding transcription factor that regulates gene expression. It has a variety of central physiological roles, including those involved in maintenance of the reproductive, cardiovascular, musculoskeletal and central nervous systems.
-The main function of the estrogen receptor is as a DNA-binding transcription factor that regulates gene expression.
 More on ER here: [http://en.wikipedia.org/wiki/RXRA].