Difference between revisions of "Part:BBa K364301"

Latest revision as of 10:15, 13 August 2010

hPUMA

PUMA

Sequence and Features

Assembly Compatibility:

10
COMPATIBLE WITH RFC[10]
12
COMPATIBLE WITH RFC[12]
21
COMPATIBLE WITH RFC[21]
23
COMPATIBLE WITH RFC[23]
25
COMPATIBLE WITH RFC[25]
1000
COMPATIBLE WITH RFC[1000]

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 member and a critical mediator of p53-dependent and -independent apoptosis induced by a wide
 variety of stimuli, including genotoxic stress, deregulated oncogene expression, toxins, altered
-redox status, growth factor/cytokine withdrawal and infection. It serves as a proximal signaling
+redox status, growth factor/cytokine withdrawal and infection.PUMA transduces death signals primarily to the mitochondria, where it acts indirectly on the Bcl-2 family members Bax and/or Bak by relieving the inhibition imposed by antiapoptotic members. It directly binds and antagonizes all known antiapoptotic Bcl-2 family members to
-molecule whose expression is regulated by transcription factors in response to these stimuli.
-PUMA transduces death signals primarily to the mitochondria, where it acts indirectly on the
-Bcl-2 family members Bax and/or Bak by relieving the inhibition imposed by antiapoptotic
-members. It directly binds and antagonizes all known antiapoptotic Bcl-2 family members to
 induce mitochondrial dysfunction and caspase activation. PUMA ablation or inhibition leads to
 apoptosis deficiency underlying increased risks for cancer development and therapeutic resistance.
-Although elevated PUMA expression elicits profound chemo- and radio-sensitization in cancer
-cells, inhibition of PUMA expression may be useful for curbing excessive cell death associated
-with tissue injury and degenerative diseases. Therefore, PUMA is a general sensor of cell death
-stimuli and a promising drug target for cancer therapy and tissue damage.
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