Difference between revisions of "Part:BBa K364301"

 
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<partinfo>BBa_K364301 short</partinfo>
 
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===Usage and Biology===
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===Usage and Biology===PUMA (p53 upregulated modulator of apoptosis) is a Bcl-2 homology 3 (BH3)-only Bcl-2 family
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member and a critical mediator of p53-dependent and -independent apoptosis induced by a wide
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variety of stimuli, including genotoxic stress, deregulated oncogene expression, toxins, altered
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redox status, growth factor/cytokine withdrawal and infection. It serves as a proximal signaling
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molecule whose expression is regulated by transcription factors in response to these stimuli.
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PUMA transduces death signals primarily to the mitochondria, where it acts indirectly on the
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Bcl-2 family members Bax and/or Bak by relieving the inhibition imposed by antiapoptotic
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members. It directly binds and antagonizes all known antiapoptotic Bcl-2 family members to
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induce mitochondrial dysfunction and caspase activation. PUMA ablation or inhibition leads to
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apoptosis deficiency underlying increased risks for cancer development and therapeutic resistance.
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Although elevated PUMA expression elicits profound chemo- and radio-sensitization in cancer
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cells, inhibition of PUMA expression may be useful for curbing excessive cell death associated
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with tissue injury and degenerative diseases. Therefore, PUMA is a general sensor of cell death
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stimuli and a promising drug target for cancer therapy and tissue damage.
  
 
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Revision as of 12:20, 11 August 2010

hPUMA

PUMA

Sequence and Features


Assembly Compatibility:
  • 10
    COMPATIBLE WITH RFC[10]
  • 12
    COMPATIBLE WITH RFC[12]
  • 21
    COMPATIBLE WITH RFC[21]
  • 23
    COMPATIBLE WITH RFC[23]
  • 25
    COMPATIBLE WITH RFC[25]
  • 1000
    COMPATIBLE WITH RFC[1000]