Difference between revisions of "Part:BBa K5382106"

 
 
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z domain refers to a synthetic protein domain that has the ability to bind to the Fc region of immunoglobulin G (IgG). In the study, z domain is used to construct extracellular vesicles (EVs) that can display antibodies, so that these EVs can bind specific antibodies through the z domain on their surface, so as to achieve targeted delivery to specific cells or tissues [
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The z domain refers to a synthetic protein domain that has the ability to bind to the Fc region of immunoglobulin G (IgG)<sup>[1]</sup>. In our project design, the z domain is used to construct extracellular vesicles (EVs) that can display antibodies, so that these EVs can bind specific antibodies through the z domain on their surface, so as to achieve targeted delivery to specific cells or tissues.<Br>
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===References===
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[1] Oscar P B Wiklander;Doste R Mamand;Dara K Mohammad;Wenyi Zheng;Rim Jawad Wiklander;Taras Sych;Antje M Zickler;Xiuming Liang;Heena Sharma;Andrea Lavado;Jeremy Bost;Samantha Roudi;Giulia Corso;Angus J Lennaárd;Manuchehr Abedi Valugerdi;Imre Mäger;Evren Alici;Erdinc Sezgin;Joel Z Nordin;Dhanu Gupta;André Görgens;Samir El Andaloussi.Antibody-displaying extracellular vesicles for targeted cancer therapy.[J].Nature biomedical engineering,2024,()
 
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===Usage and Biology===
 
===Usage and Biology===

Latest revision as of 12:26, 2 October 2024


z domain-protein domain

The z domain refers to a synthetic protein domain that has the ability to bind to the Fc region of immunoglobulin G (IgG)[1]. In our project design, the z domain is used to construct extracellular vesicles (EVs) that can display antibodies, so that these EVs can bind specific antibodies through the z domain on their surface, so as to achieve targeted delivery to specific cells or tissues.

References

[1] Oscar P B Wiklander;Doste R Mamand;Dara K Mohammad;Wenyi Zheng;Rim Jawad Wiklander;Taras Sych;Antje M Zickler;Xiuming Liang;Heena Sharma;Andrea Lavado;Jeremy Bost;Samantha Roudi;Giulia Corso;Angus J Lennaárd;Manuchehr Abedi Valugerdi;Imre Mäger;Evren Alici;Erdinc Sezgin;Joel Z Nordin;Dhanu Gupta;André Görgens;Samir El Andaloussi.Antibody-displaying extracellular vesicles for targeted cancer therapy.[J].Nature biomedical engineering,2024,() Sequence and Features


Assembly Compatibility:
  • 10
    COMPATIBLE WITH RFC[10]
  • 12
    COMPATIBLE WITH RFC[12]
  • 21
    COMPATIBLE WITH RFC[21]
  • 23
    COMPATIBLE WITH RFC[23]
  • 25
    COMPATIBLE WITH RFC[25]
  • 1000
    COMPATIBLE WITH RFC[1000]