Difference between revisions of "Part:BBa K5198003"

 
 
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Single-chain variable fragment derived from the SJ25C1 antibody, which has strong affinity for the extracellular domain of CD19 [1]. By recognizing and binding to CD19, this scFv can potentially be used in therapeutic applications, where T-cells are engineered to express the scFv on their surface, enabling them to target and destroy CD19-positive B-cells.
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===Usage and Biology===
 
  
 
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===References===
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[1] C. He et al., “CD19 CAR antigen engagement mechanisms and affinity tuning,” Sci Immunol, vol. 8, no. 81, p. eadf1426, Mar. 2023, doi: 10.1126/sciimmunol.adf1426.

Latest revision as of 09:05, 2 October 2024


antiCD19 scFv SJ25C1 WT

Single-chain variable fragment derived from the SJ25C1 antibody, which has strong affinity for the extracellular domain of CD19 [1]. By recognizing and binding to CD19, this scFv can potentially be used in therapeutic applications, where T-cells are engineered to express the scFv on their surface, enabling them to target and destroy CD19-positive B-cells.



Sequence and Features


Assembly Compatibility:
  • 10
    COMPATIBLE WITH RFC[10]
  • 12
    COMPATIBLE WITH RFC[12]
  • 21
    COMPATIBLE WITH RFC[21]
  • 23
    COMPATIBLE WITH RFC[23]
  • 25
    COMPATIBLE WITH RFC[25]
  • 1000
    COMPATIBLE WITH RFC[1000]


References

[1] C. He et al., “CD19 CAR antigen engagement mechanisms and affinity tuning,” Sci Immunol, vol. 8, no. 81, p. eadf1426, Mar. 2023, doi: 10.1126/sciimmunol.adf1426.