Difference between revisions of "Part:BBa K5499007"
 
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Lysosome-associated membrane protein 2, isoform A (LAMP2A), serves as a receptor and channel for transporting cytosolic proteins.
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Lysosome-associated membrane protein type 2A (LAMP2A) is a crucial protein involved in exosome formation.
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===Usage and Biology===
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LAMP2A is a lysosome-associated membrane protein that is involved in the loading of soluble proteins containing specific amino acid sequences (such as the KFERQ motif) into nascent exosomes located at the endosomal limiting membrane. This process is known as exosomal LAMP2A cargo loading (e-LLoC) and is related to intercellular and interorgan communication.
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===Profile===
 
===Profile===
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Name: Lysosome-associated membrane protein 2, isoform A (LAMP2A)
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Name: LAMP2A (Lysosomal-associated membrane protein 2A) mature peptide
  
 
Base Pairs:1146 bp
 
Base Pairs:1146 bp
  
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Origin: Homo sapiens, synthetic
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Origins: The LAMP2A mature peptide is derived from the lysosomal-associated membrane protein 2 (LAMP2) gene in mammals. It is processed from the precursor protein after the signal peptide is cleaved.
  
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Properties: a lysosome-associated membrane protein that serves as a receptor and channel for transporting cytosolic proteins
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Properties: LAMP2A's structure facilitates its ability to promote the selective recognition and transport of cytoplasmic proteins containing specific targeting motifs, such as the KFERQ sequence.
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===Usage and Biology===
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LAMP2A is involved in recognizing proteins destined for degradation or exosomal secretion by binding to the chaperone-protein complex at the lysosomal membrane. Upon binding, it facilitates the translocation of these proteins into the lysosome for degradation or packaging into multivesicular bodies (MVBs) for exosomal secretion. The interaction between LAMP2A and the KFERQ-like motifs allows for the selective uptake of proteins, ensuring that unwanted or misfolded proteins are efficiently handled by the cell.This positions LAMP2A as a key player in the regulation of protein sorting within cells and the modulation of extracellular signaling through exosomes.

Latest revision as of 23:23, 1 October 2024


LAMP2A mature peptide

Lysosome-associated membrane protein type 2A (LAMP2A) is a crucial protein involved in exosome formation.

Sequence and Features


Assembly Compatibility:
  • 10
    COMPATIBLE WITH RFC[10]
  • 12
    COMPATIBLE WITH RFC[12]
  • 21
    COMPATIBLE WITH RFC[21]
  • 23
    COMPATIBLE WITH RFC[23]
  • 25
    COMPATIBLE WITH RFC[25]
  • 1000
    COMPATIBLE WITH RFC[1000]


Profile

Name: LAMP2A (Lysosomal-associated membrane protein 2A) mature peptide

Base Pairs:1146 bp

Origins: The LAMP2A mature peptide is derived from the lysosomal-associated membrane protein 2 (LAMP2) gene in mammals. It is processed from the precursor protein after the signal peptide is cleaved.

Properties: LAMP2A's structure facilitates its ability to promote the selective recognition and transport of cytoplasmic proteins containing specific targeting motifs, such as the KFERQ sequence.

Usage and Biology

LAMP2A is involved in recognizing proteins destined for degradation or exosomal secretion by binding to the chaperone-protein complex at the lysosomal membrane. Upon binding, it facilitates the translocation of these proteins into the lysosome for degradation or packaging into multivesicular bodies (MVBs) for exosomal secretion. The interaction between LAMP2A and the KFERQ-like motifs allows for the selective uptake of proteins, ensuring that unwanted or misfolded proteins are efficiently handled by the cell.This positions LAMP2A as a key player in the regulation of protein sorting within cells and the modulation of extracellular signaling through exosomes.