Difference between revisions of "Part:BBa K5477017"

 
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UGT1A1 (UDP-glucuronosyltransferase 1A1) plays a crucial role in the detoxification of environmental pollutants such as dioxins, polycyclic aromatic hydrocarbons (PAHs), and polychlorinated biphenyls (PCBs) through glucuronidation, a process where glucuronic acid is added to lipophilic molecules, increasing their solubility. This reaction converts these toxic compounds into more hydrophilic metabolites, making them easier to excrete via bile or urine. By metabolizing dioxins, PAHs, and PCBs, UGT1A1 helps reduce their toxicity and potential to cause cellular damage, particularly within the liver.
 
UGT1A1 (UDP-glucuronosyltransferase 1A1) plays a crucial role in the detoxification of environmental pollutants such as dioxins, polycyclic aromatic hydrocarbons (PAHs), and polychlorinated biphenyls (PCBs) through glucuronidation, a process where glucuronic acid is added to lipophilic molecules, increasing their solubility. This reaction converts these toxic compounds into more hydrophilic metabolites, making them easier to excrete via bile or urine. By metabolizing dioxins, PAHs, and PCBs, UGT1A1 helps reduce their toxicity and potential to cause cellular damage, particularly within the liver.
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Incorporating UGT1A1 into our detoxification system together with UDPD helps detoxify these compounds. The following composites and devices, where this part was used, is listed below:
  
  

Revision as of 17:06, 26 September 2024


UGT1A1 - UDP-glucuronosyltransferase 1A1

UGT1A1 (UDP-glucuronosyltransferase 1A1) plays a crucial role in the detoxification of environmental pollutants such as dioxins, polycyclic aromatic hydrocarbons (PAHs), and polychlorinated biphenyls (PCBs) through glucuronidation, a process where glucuronic acid is added to lipophilic molecules, increasing their solubility. This reaction converts these toxic compounds into more hydrophilic metabolites, making them easier to excrete via bile or urine. By metabolizing dioxins, PAHs, and PCBs, UGT1A1 helps reduce their toxicity and potential to cause cellular damage, particularly within the liver.

Incorporating UGT1A1 into our detoxification system together with UDPD helps detoxify these compounds. The following composites and devices, where this part was used, is listed below:


Sequence and Features


Assembly Compatibility:
  • 10
    INCOMPATIBLE WITH RFC[10]
    Illegal EcoRI site found at 706
    Illegal PstI site found at 148
    Illegal PstI site found at 316
    Illegal PstI site found at 619
  • 12
    INCOMPATIBLE WITH RFC[12]
    Illegal EcoRI site found at 706
    Illegal PstI site found at 148
    Illegal PstI site found at 316
    Illegal PstI site found at 619
  • 21
    INCOMPATIBLE WITH RFC[21]
    Illegal EcoRI site found at 706
  • 23
    INCOMPATIBLE WITH RFC[23]
    Illegal EcoRI site found at 706
    Illegal PstI site found at 148
    Illegal PstI site found at 316
    Illegal PstI site found at 619
  • 25
    INCOMPATIBLE WITH RFC[25]
    Illegal EcoRI site found at 706
    Illegal PstI site found at 148
    Illegal PstI site found at 316
    Illegal PstI site found at 619
  • 1000
    COMPATIBLE WITH RFC[1000]