Difference between revisions of "Part:BBa K5387000"
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<partinfo>BBa_K5387000 short</partinfo>
 
<partinfo>BBa_K5387000 short</partinfo>
  
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===Description===  
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===Usage and Biology===
 
ALOX12B encodes for the protein Arachidonate 12-lipoxygenase, 12R-type. The primary function of Arachidonate 12-lipoxygenase, 12R-type, in the skin is the catalysis of the oxidation of linoleoyl moiety on O-linoleoyl-ω-hydroxy ceramide to form 9R-hydroperoxy- linoleoyl-ω-hydroxyceramide, a critical process in the formation of the corneocyte lipid envelope in mammalian skin [https://www.sciencedirect.com/science/article/pii/S0753332220305473#sec0010].
 
ALOX12B encodes for the protein Arachidonate 12-lipoxygenase, 12R-type. The primary function of Arachidonate 12-lipoxygenase, 12R-type, in the skin is the catalysis of the oxidation of linoleoyl moiety on O-linoleoyl-ω-hydroxy ceramide to form 9R-hydroperoxy- linoleoyl-ω-hydroxyceramide, a critical process in the formation of the corneocyte lipid envelope in mammalian skin [https://www.sciencedirect.com/science/article/pii/S0753332220305473#sec0010].
  

Revision as of 12:37, 20 August 2024

ALOX12B

Usage and Biology

ALOX12B encodes for the protein Arachidonate 12-lipoxygenase, 12R-type. The primary function of Arachidonate 12-lipoxygenase, 12R-type, in the skin is the catalysis of the oxidation of linoleoyl moiety on O-linoleoyl-ω-hydroxy ceramide to form 9R-hydroperoxy- linoleoyl-ω-hydroxyceramide, a critical process in the formation of the corneocyte lipid envelope in mammalian skin [1].

The gene codes for one of the enzymes used for iGEM24_Linkoping substitution therapy for Ichthyosis.

Sequence


Assembly Compatibility:
  • 10
    COMPATIBLE WITH RFC[10]
  • 12
    INCOMPATIBLE WITH RFC[12]
    Illegal NheI site found at 1789
  • 21
    INCOMPATIBLE WITH RFC[21]
    Illegal BglII site found at 722
    Illegal BamHI site found at 2070
  • 23
    COMPATIBLE WITH RFC[23]
  • 25
    INCOMPATIBLE WITH RFC[25]
    Illegal AgeI site found at 1747
  • 1000
    INCOMPATIBLE WITH RFC[1000]
    Illegal BsaI site found at 454

References

https://www.sciencedirect.com/science/article/pii/S0753332220305473#sec0010 UTFÖRLIGARE