Difference between revisions of "Part:BBa K4880001"
 
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<partinfo>BBa_K4880001 short</partinfo>
 
<partinfo>BBa_K4880001 short</partinfo>
  
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The sequence codes for the santalene synthase SaSS, which transforms FPP into santalene.  
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This gene encodes for the santalene synthase derived from Santalum album and has been codon optimized in cyanobacteria. This sesquiterpene synthase converts farnesyl pyrophosphate to santalene.
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===Santalene===
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Santalene and its derivative Santalol(which has an additional oxygen, forming a hydroxyl group), is an organic chemical with formula of C15H24(C15H24O for Santalol), and is a pale yellow, slightly water soluble compound with a jaw-dropping market value of about 150,000 USD per Kilogram. The fragrance is woody (since it comes from the heartwood of Tropical Sandalwood) and is commonly used in Aromatherapy to prevent inflammation. It is also noted for its ability to induce cell apoptosis for cancer cells. However, as the high price tag might have implied already, the sandalwood tree which the fragrance comes from is extremely endangered: 175 years of commercial harvesting, grazing of saplings by livestock, climate change and poaching may have decreased the population of wild sandalwood by as much as 90%.
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<center><html><img src ="https://static.igem.wiki/teams/4880/wiki/parts/santalene.jpg" width = "30%"><br></html></center>
  
 
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<partinfo>BBa_K4880001 parameters</partinfo>
 
<partinfo>BBa_K4880001 parameters</partinfo>
 
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===References===
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Blanc-Garin V, Chenebault C, Diaz-Santos E, Vincent M, Sassi JF, Cassier-Chauvat C, Chauvat F. Exploring the potential of the model cyanobacterium Synechocystis PCC 6803 for the photosynthetic production of various high-value terpenes. Biotechnol Biofuels Bioprod. 2022 Oct 14;15(1):110.

Latest revision as of 15:15, 12 October 2023


SaSS

This gene encodes for the santalene synthase derived from Santalum album and has been codon optimized in cyanobacteria. This sesquiterpene synthase converts farnesyl pyrophosphate to santalene.

Santalene

Santalene and its derivative Santalol(which has an additional oxygen, forming a hydroxyl group), is an organic chemical with formula of C15H24(C15H24O for Santalol), and is a pale yellow, slightly water soluble compound with a jaw-dropping market value of about 150,000 USD per Kilogram. The fragrance is woody (since it comes from the heartwood of Tropical Sandalwood) and is commonly used in Aromatherapy to prevent inflammation. It is also noted for its ability to induce cell apoptosis for cancer cells. However, as the high price tag might have implied already, the sandalwood tree which the fragrance comes from is extremely endangered: 175 years of commercial harvesting, grazing of saplings by livestock, climate change and poaching may have decreased the population of wild sandalwood by as much as 90%.


Sequence and Features


Assembly Compatibility:
  • 10
    INCOMPATIBLE WITH RFC[10]
    Illegal PstI site found at 862
  • 12
    INCOMPATIBLE WITH RFC[12]
    Illegal PstI site found at 862
  • 21
    COMPATIBLE WITH RFC[21]
  • 23
    INCOMPATIBLE WITH RFC[23]
    Illegal PstI site found at 862
  • 25
    INCOMPATIBLE WITH RFC[25]
    Illegal PstI site found at 862
    Illegal AgeI site found at 823
    Illegal AgeI site found at 1462
  • 1000
    INCOMPATIBLE WITH RFC[1000]
    Illegal BsaI site found at 1257


References

Blanc-Garin V, Chenebault C, Diaz-Santos E, Vincent M, Sassi JF, Cassier-Chauvat C, Chauvat F. Exploring the potential of the model cyanobacterium Synechocystis PCC 6803 for the photosynthetic production of various high-value terpenes. Biotechnol Biofuels Bioprod. 2022 Oct 14;15(1):110.