Difference between revisions of "Part:BBa K4990012"

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===Usage in short===
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You can use it to achieve BL-CRC adhesion.
 
===You need to know===
 
===You need to know===
  
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===What is it===
  
 
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Revision as of 09:51, 12 October 2023


Tumor-Targeting Rod

Usage in short

You can use it to achieve BL-CRC adhesion.

You need to know

Acurate targeting is one important characteristics for many emerging cancer therapies, that is also what ourproject’s ambition. We designed two fusion proteins, they function like fishingrod, so we gave them the name: Fishing Rod Proteins (FRPs). The one that targetFn names Bacteria Tageting Rod(BTR), the other that target CRC cells names Tumor Tageting Rod(TTR). FRPs are displayed on engineered BL membranes, helping BLtarget to the correct place. Of course, their targets are cancer cells and Fn,rather than fish. Each FRP consists of four parts (Figure1): the signal peptide(white),helping FRPs locate on cell membrane; the membrane protein(pink), the base ofFRPs; and the linker(blue), helping FRPs become flexible; and the targeting fragments(yellow), the most pivotal role in FRPs

What is it

Sequence and Features


Assembly Compatibility:
  • 10
    INCOMPATIBLE WITH RFC[10]
    Illegal PstI site found at 358
  • 12
    INCOMPATIBLE WITH RFC[12]
    Illegal PstI site found at 358
  • 21
    INCOMPATIBLE WITH RFC[21]
    Illegal BamHI site found at 771
  • 23
    INCOMPATIBLE WITH RFC[23]
    Illegal PstI site found at 358
  • 25
    INCOMPATIBLE WITH RFC[25]
    Illegal PstI site found at 358
    Illegal NgoMIV site found at 1050
    Illegal NgoMIV site found at 1590
  • 1000
    COMPATIBLE WITH RFC[1000]