Difference between revisions of "Part:BBa K4785005"

Revision as of 12:03, 10 October 2023

high-mobility group box 1 (hmgb1)

A protein from the High Mobility Group-box superfamily is produced by this gene. The nuclear DNA-binding, non-histone protein that is encoded controls transcription and contributes to DNA organization. This protein participates in a number of biological activities, such as cell differentiation, inflammation, and tumor cell migration. This gene has several recognized pseudogenes. Multiple transcript variants that encode the same protein are produced through alternative splicing. Recent studies have found that the structure of HMGB1 is similar to DNABII protein in biofilm, which is responsible for stabilizing eDNA structure. Therefore, HMGB1 can be used to inhibit the growth of biofilm and disrupt mature biofilm. Therefore, our team registered this gene for the convenience of our team and subsequent teams.

Sequence and Features

Assembly Compatibility:

10
COMPATIBLE WITH RFC[10]
12
COMPATIBLE WITH RFC[12]
21
COMPATIBLE WITH RFC[21]
23
COMPATIBLE WITH RFC[23]
25
COMPATIBLE WITH RFC[25]
1000
INCOMPATIBLE WITH RFC[1000]
Illegal SapI.rc site found at 73

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 <partinfo>BBa_K4785005 short</partinfo>
-This DNA sequence was used to express the HMGB1_A box. HMGB1_A box is a part of HMGB1 protein. The DNABII protein monomer responsible for stabilizing the eDNA structure in biofilm has a similar structure to HMGB1_A box. Therefore, we hypothesized that HMGB1_A box could inhibit the growth of biofilm and disrupt the mature biofilm. Therefore, we truncated the sequence of hmgb1 to obtain the present sequence, and recorded it on this page for the convenience of our team and other teams.
+A protein from the High Mobility Group-box superfamily is produced by this gene. The nuclear DNA-binding, non-histone protein that is encoded controls transcription and contributes to DNA organization. This protein participates in a number of biological activities, such as cell differentiation, inflammation, and tumor cell migration. This gene has several recognized pseudogenes. Multiple transcript variants that encode the same protein are produced through alternative splicing. Recent studies have found that the structure of HMGB1 is similar to DNABII protein in biofilm, which is responsible for stabilizing eDNA structure. Therefore, HMGB1 can be used to inhibit the growth of biofilm and disrupt mature biofilm. Therefore, our team registered this gene for the convenience of our team and subsequent teams.
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