Difference between revisions of "Part:BBa K4989003"

Revision as of 14:28, 8 October 2023

Butyrylo-CoA dehydrogenase (bcd)

It is an improved basic part of:

BBa_K1618043 of iGEM 2015 NRP-UEA-Norwich.

Alternative names of the enzyme

Other names that the butyryl-CoA dehydrogease enzyme could be found in the bibliography are:
Systematic name: short-chain acyl-CoA:electron-transfer flavoprotein 2,3-oxidoreductase
Else: short-chain acyl-CoA dehydrogenase,
butyryl-CoA dehydrogenase,
butanoyl-CoA dehydrogenase,
butyryl dehydrogenase,
unsaturated acyl-CoA reductase,
ethylene reductase,
enoyl-coenzyme A reductase, unsaturated acyl coenzyme A reductase,
butyryl coenzyme A dehydrogenase,
short-chain acyl CoA dehydrogenase, short-chain acyl-coenzyme A dehydrogenase,
3-hydroxyacyl CoA reductase,
butanoyl-CoA:(acceptor) 2,3-oxidoreductase, ACADS (gene name)

Application in the field of biology

The bcd gene encodes for a flavoprotein oxidoreductase that has great specificity for short-chain fatty acids: butyryl-CoA dehydrogenase. The enzyme catalyzes the a and b desaturation of acyl-CoA substrates[1]. This enzyme doesn’t utilize NAD(H) directly but requires electron transfer flavoproteins to form a complex and transfer electrons from butyryl-CoA dehydrogenase to NAD(H)[2].
The full reaction is shown below:
2 NADH+2Fdox + crotonyl−CoA↔2 NAD+2 Fdred+ butyryl−CoA