Difference between revisions of "Part:BBa K4656002"
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− | + | TPH also plays a crucial role in the synthesis of serotonin, where the rate-limiting step is catalyzed by TPH to convert tryptophan (an essential amino acid) to 5-hydroxytryptophan (5-HTP). | |
+ | <html><BR><BR><center><img style="display: block;-webkit-user-select: none;margin: auto;cursor: zoom-in;background-color: hsl(0,0%,90%);transition: background-color 300ms;" src="https://static.igem.wiki/teams/4656/wiki/tdc-tph.jpg" width="600" height="200"></center></html> | ||
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+ | <center><b>The synthesis of 5-HT </b></center> | ||
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===Usage and Biology=== | ===Usage and Biology=== | ||
− | As a neurotransmitter, serotonin | + | As a neurotransmitter, serotonin plays a role in intestinal motility. If secretion in the gut is insufficient, it can easily lead to the decline of intestinal motility, and then lead to chronic constipation. Therefore, promoting TPH expression is conducive to the treatment of chronic constipation. Experimental results about our 5-HT producing circuit can be found in our composite part BBa K4656007. |
+ | <html><BR><BR><center><img style="display: block;-webkit-user-select: none;margin: auto;cursor: zoom-in;background-color: hsl(0,0%,90%);transition: background-color 300ms;" src="https://static.igem.wiki/teams/4656/wiki/part-plam-tph-tdc.jpg" width="600" height="300"></center></html> | ||
===Sequence and Features=== | ===Sequence and Features=== |
Latest revision as of 12:42, 5 October 2023
TPH
TPH also plays a crucial role in the synthesis of serotonin, where the rate-limiting step is catalyzed by TPH to convert tryptophan (an essential amino acid) to 5-hydroxytryptophan (5-HTP).
Usage and Biology
As a neurotransmitter, serotonin plays a role in intestinal motility. If secretion in the gut is insufficient, it can easily lead to the decline of intestinal motility, and then lead to chronic constipation. Therefore, promoting TPH expression is conducive to the treatment of chronic constipation. Experimental results about our 5-HT producing circuit can be found in our composite part BBa K4656007.
Sequence and Features
Assembly Compatibility:
- 10COMPATIBLE WITH RFC[10]
- 12INCOMPATIBLE WITH RFC[12]Illegal NheI site found at 898
- 21COMPATIBLE WITH RFC[21]
- 23COMPATIBLE WITH RFC[23]
- 25INCOMPATIBLE WITH RFC[25]Illegal AgeI site found at 673
- 1000INCOMPATIBLE WITH RFC[1000]Illegal SapI.rc site found at 240