Difference between revisions of "Part:BBa K4586024"

 
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<partinfo>BBa_K4586024 short</partinfo>
 
<partinfo>BBa_K4586024 short</partinfo>
  
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this composite part is an artificial receptor based on the core regulatory domain of mechanosensitive notch receptors (mouse notch) and uses an artificial sensor (extracellular domain) and transcription mediator within the internal domain.
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==Description==
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This composite parts codes for a synthetic receptor sensitive for the autoreactive B-cell receptor secreting ACPAs.
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vimentin syn notch receptor consists of three main domains, first the extracellular domain represented in tagged citrullinated vimentin conjugated to CD8 alpha signal that mediate the the expression of the receptor on the cell membrane, second the transmembrane domain represented in mouse notch core protein that is is characterized by mechanosensitive structure that transfer the signal from the extracellular domain to the third intracellular domain that contains our potent transcription module VP64 which trigger the expression of our therapeutic agent (Cas12k\gBAFF-R).  
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==Usage==
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<!-- Add more about the biology of this part here
 
<!-- Add more about the biology of this part here

Revision as of 10:50, 21 September 2023


CCP1-Synthetic Notch Receptor

Description

This composite parts codes for a synthetic receptor sensitive for the autoreactive B-cell receptor secreting ACPAs. vimentin syn notch receptor consists of three main domains, first the extracellular domain represented in tagged citrullinated vimentin conjugated to CD8 alpha signal that mediate the the expression of the receptor on the cell membrane, second the transmembrane domain represented in mouse notch core protein that is is characterized by mechanosensitive structure that transfer the signal from the extracellular domain to the third intracellular domain that contains our potent transcription module VP64 which trigger the expression of our therapeutic agent (Cas12k\gBAFF-R).

Usage

Sequence and Features


Assembly Compatibility:
  • 10
    COMPATIBLE WITH RFC[10]
  • 12
    INCOMPATIBLE WITH RFC[12]
    Illegal NotI site found at 774
    Illegal NotI site found at 783
  • 21
    INCOMPATIBLE WITH RFC[21]
    Illegal BglII site found at 614
  • 23
    COMPATIBLE WITH RFC[23]
  • 25
    COMPATIBLE WITH RFC[25]
  • 1000
    INCOMPATIBLE WITH RFC[1000]
    Illegal SapI.rc site found at 1399