Difference between revisions of "Part:BBa K4586001"

 
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<partinfo>BBa_K4586001 short</partinfo>
 
<partinfo>BBa_K4586001 short</partinfo>
  
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It is a notch-derived transmembrane regulatory protein that regulates cell fate decisions during a variety of developmental processes. It was first identified in beaded winged flies, and its structure can be divided into the Notch extracellular domain and Notch intracellular domain joined together by a single-pass transmembrane domain
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==Part Description==
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This part codes for an enhanced Mouse notch core, which is a notch-derived transmembrane regulatory protein that normally  regulates cell fate decisions during a variety of developmental processes. It was first identified in beaded winged flies. The activity of the synthetic notch is determined by the sequential cleavage of its domain carried out by protease enzymes after cell interaction with another cell.
  
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==Usage==
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Mouse notch is implicated in our design as the transmembrane domain of our Syn notch receptor as it transmits the signal that is started by cell-to-cell contact between the external domain and the autoreactive B cells through it’s mechanosensitive quality based on proteolytic cleavage of its domains to release our intra-cellular transcription module (ZF21.16 VP64) that activates the ZF21.16) promoter controlling the expression of our cargo.
 
<!-- Add more about the biology of this part here
 
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===Usage and Biology===
 
===Usage and Biology===

Revision as of 09:32, 20 September 2023


Mouse notch core

Part Description

This part codes for an enhanced Mouse notch core, which is a notch-derived transmembrane regulatory protein that normally regulates cell fate decisions during a variety of developmental processes. It was first identified in beaded winged flies. The activity of the synthetic notch is determined by the sequential cleavage of its domain carried out by protease enzymes after cell interaction with another cell.

Usage

Mouse notch is implicated in our design as the transmembrane domain of our Syn notch receptor as it transmits the signal that is started by cell-to-cell contact between the external domain and the autoreactive B cells through it’s mechanosensitive quality based on proteolytic cleavage of its domains to release our intra-cellular transcription module (ZF21.16 VP64) that activates the ZF21.16) promoter controlling the expression of our cargo. Sequence and Features


Assembly Compatibility:
  • 10
    COMPATIBLE WITH RFC[10]
  • 12
    COMPATIBLE WITH RFC[12]
  • 21
    COMPATIBLE WITH RFC[21]
  • 23
    COMPATIBLE WITH RFC[23]
  • 25
    COMPATIBLE WITH RFC[25]
  • 1000
    INCOMPATIBLE WITH RFC[1000]
    Illegal SapI.rc site found at 592