Difference between revisions of "Part:BBa K4607008"

The biobrick consists of the polycationic nonapeptide (PCNP) which is capable to destabilize the lipopolysaccharide binds on Gram-negative baterium. The principle about the PCNP is related to the ionic interactions between the phosphate groups, divalent cations, and hyrdophobic lipids' stacking, where the PCNP acts as a destabilizing. This part has been fused with endolysins in order to increase their capability to lyse Gram-negative bacterium, demonstrating that the addition of the PCNP allows the endolysin introduction into the bacteria cell membrane. It part have been evaluated in Escherichia coli. The peptide has a lenght of nine amino acids.

Sequence and Features

Usage and Biology