Difference between revisions of "Part:BBa K4990001"

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Revision as of 12:00, 20 August 2023


FK-13

Antimicrobial peptides are widely sourced, first discovered in the immune systems of insects. Subsequently, similar peptides have been extracted from bacteria, fungi, amphibians, higher plants, and mammals. These active peptides possess natural immune functions and serve as essential molecular barriers for host defense against invading pathogens, hence referred to as antimicrobial peptides.

The tissue proteinase inhibitor family is unique to mammals and constitutes a type of antimicrobial peptide. Among them, LL-37 is the sole antimicrobial peptide found in the human body. It possesses various functions such as antimicrobial, antitoxin, immunomodulatory, and wound healing effects. Additionally, LL-37 holds potential for treating viral diseases and neoplastic conditions. Numerous research teams have investigated the activity of truncated peptides to identify the minimal antimicrobial region of LL-37. The results indicate that the smallest region of LL-37 is within amino acid positions 17 to 29 or 18 to 29. This suggests that the C-terminal helix of LL-37 plays a role in antimicrobial, antiviral, and antitumor activities.

Introduction

This part is the truncated peptide of LL37, representing the minimal functional segment of LL37. It consists of only 13 AA and exhibits antimicrobial activity.

在这里写你的文字内容，在图片的左侧紧密型环绕。

Sequence and Features


Assembly Compatibility:
  • 10
    COMPATIBLE WITH RFC[10]
  • 12
    COMPATIBLE WITH RFC[12]
  • 21
    COMPATIBLE WITH RFC[21]
  • 23
    COMPATIBLE WITH RFC[23]
  • 25
    COMPATIBLE WITH RFC[25]
  • 1000
    COMPATIBLE WITH RFC[1000]