Difference between revisions of "Part:BBa K4607003"
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| − | To increase the sensitivity of the enzyme for pathogenic bacteria, specifically <i>Streptococcus uberis, Staphylococcus aureus, and Streptococcus agalactiae</i>, the SH3 domain from the B30 bacteriophage was selected, which makes it completely safe for the host [ | + | To increase the sensitivity of the enzyme for pathogenic bacteria, specifically <i>Streptococcus uberis, Staphylococcus aureus, and Streptococcus agalactiae</i>, the SH3 domain from the B30 bacteriophage was selected, which makes it completely safe for the host [1]. The use of enzybiotics represents an alternative to the misuse of antibiotics without loss of efficiency; it is a novel and environmentally friendly process. It supplies antibacterial protection to pathogenic bacteria but shows no toxic effects on mammalian cells. |
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===Results=== | ===Results=== | ||
Revision as of 07:01, 21 July 2023
SH3B30 Domain
The Sh3 domain from the bacteriophage B30 is capable of recognizing and binding to the cell wall of Streptococcus agalactiae, Streptococcus uberis, and Staphylococcus aureus. It keeps its stability in a range of 4 to 37°C and pH from 7 to 8 [1].
Sequence and Features
- 10COMPATIBLE WITH RFC[10]
- 12COMPATIBLE WITH RFC[12]
- 21COMPATIBLE WITH RFC[21]
- 23COMPATIBLE WITH RFC[23]
- 25COMPATIBLE WITH RFC[25]
- 1000COMPATIBLE WITH RFC[1000]
Usage and Biology
To increase the sensitivity of the enzyme for pathogenic bacteria, specifically Streptococcus uberis, Staphylococcus aureus, and Streptococcus agalactiae, the SH3 domain from the B30 bacteriophage was selected, which makes it completely safe for the host [1]. The use of enzybiotics represents an alternative to the misuse of antibiotics without loss of efficiency; it is a novel and environmentally friendly process. It supplies antibacterial protection to pathogenic bacteria but shows no toxic effects on mammalian cells.