Difference between revisions of "Part:BBa K4165259"
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This composite part encodes for WWW peptide which binds to misfolded tau protein (BBa_K4165007) tagged with a GST tag (BBa_K4165070). | This composite part encodes for WWW peptide which binds to misfolded tau protein (BBa_K4165007) tagged with a GST tag (BBa_K4165070). | ||
Latest revision as of 15:08, 12 October 2022
GST-WWW
This composite part encodes for WWW peptide which binds to misfolded tau protein (BBa_K4165007) tagged with a GST tag (BBa_K4165070).
Usage and Biology
WWW is a synthetic peptide designed to bind to microtubule associated protein tau (MAPT) at the PHF motif which is reported to drive the accumulation of paired helical filaments form of tau resulting in tau aggregates related diseases which are mostly related to dementia. It is fused to GST tag for purification.
Sequence and Features
Assembly Compatibility:
- 10COMPATIBLE WITH RFC[10]
- 12COMPATIBLE WITH RFC[12]
- 21COMPATIBLE WITH RFC[21]
- 23COMPATIBLE WITH RFC[23]
- 25COMPATIBLE WITH RFC[25]
- 1000INCOMPATIBLE WITH RFC[1000]Illegal SapI.rc site found at 85