Difference between revisions of "Part:BBa K4165192"
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Type of Amyloid-beta binding peptide start from amino acid 32 to 42, this peptide characterized by its solubility which is 22 ± 9 μM, highly toxic effect | Type of Amyloid-beta binding peptide start from amino acid 32 to 42, this peptide characterized by its solubility which is 22 ± 9 μM, highly toxic effect | ||
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Figure 1.: Amyloid-beta (29-42) top model visualized by Pymol. | Figure 1.: Amyloid-beta (29-42) top model visualized by Pymol. | ||
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<partinfo>BBa_K4165192 parameters</partinfo> | <partinfo>BBa_K4165192 parameters</partinfo> | ||
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Revision as of 17:51, 10 October 2022
Amyloid beta peptide 12 (Aβ 29-42)
This part encodes a part of the Amyloid 𝛽 fragment (29-42) which has the ability to bind to A𝛽 plaques inside the brain.
Usage and Biology
Type of Amyloid-beta binding peptide start from amino acid 32 to 42, this peptide characterized by its solubility which is 22 ± 9 μM, highly toxic effect
Sequence and Features
- 10COMPATIBLE WITH RFC[10]
- 12COMPATIBLE WITH RFC[12]
- 21COMPATIBLE WITH RFC[21]
- 23COMPATIBLE WITH RFC[23]
- 25COMPATIBLE WITH RFC[25]
- 1000COMPATIBLE WITH RFC[1000]
Features and codon optimize
This sequence is optimized for E. coli bacteria
Source
Homo sapiens Amyloid-beta precursor protein - UniProt (P05067)
References
Zhao, Y., Cai, J., Liu, Z., Li, Y., Zheng, C., Zheng, Y., ... & Liu, Y. (2018). Nanocomposites inhibit the formation, mitigate the neurotoxicity, and facilitate the removal of β-amyloid aggregates in Alzheimer’s disease mice. Nano letters, 19(2), 674-683.
Dry lab
Modeling
Due to the nonavailability of a model to this peptide we modeled it in our used modeling software's and after the Running of the quality assessment, the models have been scored to get the top model.
Figure 1.: Amyloid-beta (29-42) top model visualized by Pymol.