Difference between revisions of "Part:BBa K4165226"

 
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flexible linker with 5 aa sequence
 
flexible linker with 5 aa sequence
  
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===Usage and Biology===
 
===Usage and Biology===
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A flexible linker with G and S aa residues with variable lengths. According to our project, 3 flexible linker required one for our clamps for binding of Tau or amyloid beta with our binding paptides . Second one for flexible linking between clamps and HTRA1 binding peptide . last one for binding our HTRA1 binding peptide with PDZ domain of our protease HTRA1. our linker with length [6 aa GGSGGG ] was calculated by our team for testing how it would affect interaction of our mentioned parts with each other using Pymol Software.
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<partinfo>BBa_K4165226 SequenceAndFeatures</partinfo>
 
<partinfo>BBa_K4165226 SequenceAndFeatures</partinfo>
  
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===References===
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1- Yuan, S., Chan, H. S., & Hu, Z. (2017). Using pymol as a platform for computational drug design. WIREs Computational Molecular Science, 7(2). doi:10.1002/wcms.1298
  
 
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Revision as of 08:01, 8 October 2022


Linker GGSGG

flexible linker with 5 aa sequence

Usage and Biology

A flexible linker with G and S aa residues with variable lengths. According to our project, 3 flexible linker required one for our clamps for binding of Tau or amyloid beta with our binding paptides . Second one for flexible linking between clamps and HTRA1 binding peptide . last one for binding our HTRA1 binding peptide with PDZ domain of our protease HTRA1. our linker with length [6 aa GGSGGG ] was calculated by our team for testing how it would affect interaction of our mentioned parts with each other using Pymol Software.


Sequence and Features


Assembly Compatibility:
  • 10
    COMPATIBLE WITH RFC[10]
  • 12
    COMPATIBLE WITH RFC[12]
  • 21
    COMPATIBLE WITH RFC[21]
  • 23
    COMPATIBLE WITH RFC[23]
  • 25
    COMPATIBLE WITH RFC[25]
  • 1000
    COMPATIBLE WITH RFC[1000]

References

1- Yuan, S., Chan, H. S., & Hu, Z. (2017). Using pymol as a platform for computational drug design. WIREs Computational Molecular Science, 7(2). doi:10.1002/wcms.1298