Difference between revisions of "Part:BBa K4165109"
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Figure 1.: 3D Model of H1O peptide Modelled by AlphaFold2.0 displayed in Pyomol | Figure 1.: 3D Model of H1O peptide Modelled by AlphaFold2.0 displayed in Pyomol | ||
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===References=== | ===References=== | ||
Revision as of 21:02, 6 October 2022
HTRA Binding Peptide 15
part encodes for a synthetic peptide that binds to the PDZ domain of HTRA1 protein
Usage and Biology
decameric peptide, Binds specifically to PDZ domain of HTRA1 Protein with G of 10.3 ± 0.2 kcal/mol.
Sequence and Features
Assembly Compatibility:
- 10COMPATIBLE WITH RFC[10]
- 12COMPATIBLE WITH RFC[12]
- 21COMPATIBLE WITH RFC[21]
- 23COMPATIBLE WITH RFC[23]
- 25COMPATIBLE WITH RFC[25]
- 1000COMPATIBLE WITH RFC[1000]
Functional Parameters
Got score of 4 out of 6 in our Quality assessment code after modeling by AlphaFold2.0
cbeta_deviations = 0, clashscore = 17.86, molprobity = 4, ramachandran_favored = 62.5, ramachandran_outliers = 12.5, Qmean_4 = -6.45183, Qmean6 = -5.513969
Modeling
Figure 1.: 3D Model of H1O peptide Modelled by AlphaFold2.0 displayed in Pyomol
References
Rey, J., Breiden, M., Lux, V., Bluemke, A., Steindel, M., Ripkens, K., ... & Ehrmann, M. (2022). An allosteric HTRA1-calpain 2 complex with restricted activation profile. Proceedings of the National Academy of Sciences, 119(14), e2113520119.