Difference between revisions of "Part:BBa K4165186"

 
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<partinfo>BBa_K4165186 short</partinfo>
 
<partinfo>BBa_K4165186 short</partinfo>
  
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This part encodes a part of the Amyloid &#120573; fragment (31-42) which has the ability to bind to A&#120573; plaques inside the brain.
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This part encodes a part of the Amyloid &#120573; fragment (39-42) which has the ability to bind to A&#120573; plaques inside the brain.
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===Usage and Biology===
 
===Usage and Biology===
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Segments of amyloid beta fibrils are widely used as a recognition sequence for amyloid beta plaques inside the brain, this is due to the homotypic interactions in the C-terminus of fibrils.
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This peptide was one of the higher acting regarding the inhibitory effect of Aβ oligomers, its small size may facilitate its use in different modified drugs for AD.
  
 
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<partinfo>BBa_K4165186 parameters</partinfo>
 
<partinfo>BBa_K4165186 parameters</partinfo>
 
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===References===
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Fradinger, E., Monien, B., Urbanc, B., Lomakin, A., Tan, M., & Li, H. et al. (2008). C-terminal peptides coassemble into Aβ42 oligomers and protect neurons against Aβ42-induced neurotoxicity. Proceedings Of The National Academy Of Sciences, 105(37), 14175-14180. doi: 10.1073/pnas.0807163105

Revision as of 13:25, 6 October 2022


Amyloid β Peptide 6 (Aβ 39-42)

This part encodes a part of the Amyloid 𝛽 fragment (39-42) which has the ability to bind to A𝛽 plaques inside the brain.


Usage and Biology

Segments of amyloid beta fibrils are widely used as a recognition sequence for amyloid beta plaques inside the brain, this is due to the homotypic interactions in the C-terminus of fibrils.

This peptide was one of the higher acting regarding the inhibitory effect of Aβ oligomers, its small size may facilitate its use in different modified drugs for AD.

Sequence and Features


Assembly Compatibility:
  • 10
    COMPATIBLE WITH RFC[10]
  • 12
    COMPATIBLE WITH RFC[12]
  • 21
    COMPATIBLE WITH RFC[21]
  • 23
    COMPATIBLE WITH RFC[23]
  • 25
    COMPATIBLE WITH RFC[25]
  • 1000
    COMPATIBLE WITH RFC[1000]


References

Fradinger, E., Monien, B., Urbanc, B., Lomakin, A., Tan, M., & Li, H. et al. (2008). C-terminal peptides coassemble into Aβ42 oligomers and protect neurons against Aβ42-induced neurotoxicity. Proceedings Of The National Academy Of Sciences, 105(37), 14175-14180. doi: 10.1073/pnas.0807163105