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===Usage and Biology===
 
===Usage and Biology===
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TLKIVW is a hexapeptide designed using Rosetta software to bind to VQIVYK steric zipper motif of tau fibers, which is from primarily reasons for the Alzheimer’s disease and other dementia related diseases, also it can prevent further accumulation of tau fibrils.
  
 
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Revision as of 16:51, 5 October 2022


TLKIVW Peptide

Tau binding peptide targeting the PHF seed of Tau

Sequence and Features


Assembly Compatibility:
  • 10
    COMPATIBLE WITH RFC[10]
  • 12
    COMPATIBLE WITH RFC[12]
  • 21
    COMPATIBLE WITH RFC[21]
  • 23
    COMPATIBLE WITH RFC[23]
  • 25
    COMPATIBLE WITH RFC[25]
  • 1000
    COMPATIBLE WITH RFC[1000]


Dry Lab

Modeling

TLKIVW were modeled by AlphaFold2 and Apptest. The best model obtained from Apptest 


                            Figure 1: Predicted 3D structure of Synthetic peptide TLKIVW.


Table 1: Quality assessment parameters of TLKIVW model.


References

1.Sievers, S. A., Karanicolas, J., Chang, H. W., Zhao, A., Jiang, L., Zirafi, O., ... & Eisenberg, D. (2011). Structure-based design of non-natural amino-acid inhibitors of amyloid fibril formation. Nature, 475(7354), 96-100.