Difference between revisions of "Part:BBa K4164003"

Revision as of 14:44, 3 October 2022

Retinoid X receptor-alpha(RXRα)

Retinoid X receptor alpha (RXR-alpha), also known as NR2B1 (nuclear receptor subfamily 2, group B, member 1) is a nuclear receptor that in humans is encoded by the RXRA gene. RXRs are associated with multiple cellular processes from cell proliferation to cell metabolism. RXRs have the ability to dimer with multiple nuclear receptors, and binding of RXR ligands to heterodimers can stimulate transcriptional activation of RXR chaperone receptors.

In the human body, RXR can bind to the farnesoid X receptor (FXR) as a heterodimer, regulating the metabolic processes of bile acid (BA), lipid, and glucose.

Sequence and Features

Assembly Compatibility:

10
COMPATIBLE WITH RFC[10]
12
COMPATIBLE WITH RFC[12]
21
COMPATIBLE WITH RFC[21]
23
COMPATIBLE WITH RFC[23]
25
INCOMPATIBLE WITH RFC[25]
Illegal NgoMIV site found at 357
1000
INCOMPATIBLE WITH RFC[1000]
Illegal BsaI.rc site found at 739

The gene sequence of this part was obtained from NCBI and its GenBank Accession number is NP_002948.1.

@@ Line 3: / Line 3: @@
 <partinfo>BBa_K4164003 short</partinfo>
-The retinoid X receptor (RXR) is a protein derived from humans. It is a type of nuclear receptor that is activated by 9-cis retinoic acid.
+Retinoid X receptor alpha (RXR-alpha), also known as NR2B1 (nuclear receptor subfamily 2, group B, member 1) is a nuclear receptor that in humans is encoded by the RXRA gene.
 RXRs are associated with multiple cellular processes from cell proliferation to cell metabolism. RXRs have the ability to dimer with multiple nuclear receptors, and binding of RXR ligands to heterodimers can stimulate transcriptional activation of RXR chaperone receptors.