Difference between revisions of "Part:BBa K3512002"

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In absence of the antitoxin CcdA, the CcdB toxin traps DNA-gyrase cleavable complexes, inducing breaks into DNA and cell death.
 
In absence of the antitoxin CcdA, the CcdB toxin traps DNA-gyrase cleavable complexes, inducing breaks into DNA and cell death.
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===Usage and Biology===
 
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<span class="mw-headline" id="Usage_and_Biology">Usage and Biology</span>
 
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<span class='mw-headline'>Sequence and Features</span>
 
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<partinfo>BBa_K3512002 Sewuence And Features</partinfo>
 
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===Functional Parameters===
 
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<partinfo>BBa_K3512002 parameters</partinfo>
 
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Latest revision as of 03:25, 7 September 2022


CcdA Antitoxin

CcdA antitoxin is part of the CcdA-CcdB toxin-antitoxin system. The target of CcdB is the GyrA subunit of DNA gyrase, an essential type II topoisomerase in Escherichia coli. Gyrase alters DNA topology by effecting a transient double-strand break in the DNA backbone, passing the double helix through the gate and resealing the gaps. The CcdB toxin acts by trapping DNA gyrase in a cleaved complex with the gyrase A subunit covalently closed to the cleaved DNA, causing DNA breakage and cell death in a way closely related to quinolones antibiotics.

In absence of the antitoxin CcdA, the CcdB toxin traps DNA-gyrase cleavable complexes, inducing breaks into DNA and cell death.