Difference between revisions of "Part:BBa K4175001"
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===Usage and Biology===
 
===Usage and Biology===
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===References===
 
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[1] Morsut, L., Roybal, K.T., Xiong, X., Gordley, R.M., Coyle, S.M., Thomson, M., Lim, W.A., 2016. Engineering Customized Cell Sensing and Response Behaviors Using Synthetic Notch Receptors. Cell 164, 780–791. https://doi.org/10.1016/j.cell.2016.01.012
 
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Revision as of 12:38, 27 August 2022


Notch core

This protein domain is derived from the transmembrane part of the Notch protein. When the extracellular domain of Notch binds to its ligand Delta, the Notch core domain will undergo intramembrane proteolysis, releasing the intracellular domain. The released intracellular domain acts as a transcriptional regulator, affecting the cellular activity. The extracellular and intracellular domain can be artificially swapped, offering a tool for designing novel signaling pathways [1].

Sequence and Features


Assembly Compatibility:
  • 10
    INCOMPATIBLE WITH RFC[10]
    Illegal PstI site found at 115
    Illegal PstI site found at 156
    Illegal PstI site found at 202
  • 12
    INCOMPATIBLE WITH RFC[12]
    Illegal PstI site found at 115
    Illegal PstI site found at 156
    Illegal PstI site found at 202
  • 21
    COMPATIBLE WITH RFC[21]
  • 23
    INCOMPATIBLE WITH RFC[23]
    Illegal PstI site found at 115
    Illegal PstI site found at 156
    Illegal PstI site found at 202
  • 25
    INCOMPATIBLE WITH RFC[25]
    Illegal PstI site found at 115
    Illegal PstI site found at 156
    Illegal PstI site found at 202
    Illegal NgoMIV site found at 28
  • 1000
    COMPATIBLE WITH RFC[1000]