Difference between revisions of "Part:BBa K3861007"
| Line 3: | Line 3: | ||
<partinfo>BBa_K3861007 short</partinfo> | <partinfo>BBa_K3861007 short</partinfo> | ||
| − | FimH is the distal protein found at the tip of the type 1 fimbriae.<sup>1</sup> | + | FimH is the distal protein found at the tip of the type 1 fimbriae.<sup>1</sup> The type 1 fimbriae plays a role in the adherence of <i> Salmonella </i> Typhimurium to the host cells, whereby mannose-containing glycoproteins can be bound by FimH. <br> |
| + | As a part of our project "Target Taxi", we aim to fuse rBC2LCN (<a href="https://parts.igem.org/Part:BBa_K3861001"> BBa_K3861001</a>), a lectin able to bind specifically to several cancer cell types, to FimH for surface display. | ||
| + | |||
| + | |||
| + | |||
| + | |||
<!-- Add more about the biology of this part here | <!-- Add more about the biology of this part here | ||
===Usage and Biology=== | ===Usage and Biology=== | ||
Revision as of 15:59, 21 October 2021
fimH
FimH is the distal protein found at the tip of the type 1 fimbriae.1 The type 1 fimbriae plays a role in the adherence of Salmonella Typhimurium to the host cells, whereby mannose-containing glycoproteins can be bound by FimH.
As a part of our project "Target Taxi", we aim to fuse rBC2LCN (<a href="https://parts.igem.org/Part:BBa_K3861001"> BBa_K3861001</a>), a lectin able to bind specifically to several cancer cell types, to FimH for surface display.
Sequence and Features
Assembly Compatibility:
- 10COMPATIBLE WITH RFC[10]
- 12COMPATIBLE WITH RFC[12]
- 21COMPATIBLE WITH RFC[21]
- 23COMPATIBLE WITH RFC[23]
- 25COMPATIBLE WITH RFC[25]
- 1000COMPATIBLE WITH RFC[1000]
References
1. Kisiela, D. I. et al. Allosteric catch bond properties of the fimh adhesin from Salmonella enterica serovar typhimurium. J. Biol. Chem. (2011) doi:10.1074/jbc.M111.237511.