Difference between revisions of "Part:BBa K4020002"
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==Usage and Biology==
 
==Usage and Biology==
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"Sic1∆N" is a gene encoding a protein that inhibits cyclin-dependent kinase complexes and G1 to S phase progression in cell cycle (Hegde, 2010), prevents premature S phase entry, and warrants genome integrity (SIC1 | SGD). It is genomic DNA with a deleted sequence of the first 90 nucleotides encoding the N-terminus of the corresponding protein.
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SIC1∆N is a gene encoding a protein that inhibits cyclin-dependent kinase complexes and G1 to S phase progression in cell cycle (Hegde, 2010a), prevents premature S phase entry, and warrants genome integrity (Hegde, 2010b). It is genomic DNA. The deletion of the first 90 nucleotides encoding the N-terminus, or the regulatory domain of the corresponding protein, results in a non-degradable ''Sic1'' variant.
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==References==
 
==References==
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*Hegde, A. N. (2010). Ubiquitin-Dependent Protein Degradation. Comprehensive Natural Products II: Chemistry and Biology, 5, 699–752. https://doi.org/10.1016/B978-008045382-8.00697-3
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*Hegde, A.N. (2010a). Ubiquitin-Dependent Protein Degradation. Comprehensive Natural Products II: Chemistry and Biology 5, 699–752.
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*SIC1 | SGD. (n.d.). Retrieved October 17, 2021, from https://www.yeastgenome.org/locus/S000004069
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*Hegde, A.N. (2010b). 5.21 - Ubiquitin-Dependent Protein Degradation. In Comprehensive Natural Products II, H.-W. (Ben) Liu, and L. Mander, eds. (Oxford: Elsevier), pp. 699–752.

Latest revision as of 04:39, 21 October 2021

Usage and Biology

SIC1∆N is a gene encoding a protein that inhibits cyclin-dependent kinase complexes and G1 to S phase progression in cell cycle (Hegde, 2010a), prevents premature S phase entry, and warrants genome integrity (Hegde, 2010b). It is genomic DNA. The deletion of the first 90 nucleotides encoding the N-terminus, or the regulatory domain of the corresponding protein, results in a non-degradable Sic1 variant.

References

  • Hegde, A.N. (2010a). Ubiquitin-Dependent Protein Degradation. Comprehensive Natural Products II: Chemistry and Biology 5, 699–752.
  • Hegde, A.N. (2010b). 5.21 - Ubiquitin-Dependent Protein Degradation. In Comprehensive Natural Products II, H.-W. (Ben) Liu, and L. Mander, eds. (Oxford: Elsevier), pp. 699–752.