Difference between revisions of "Part:BBa K3846007"
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Revision as of 17:00, 12 October 2021


Costunolide synthase (CYP71BL2)

Involved in the biosynthesis of germacrene-derived sesquiterpene lactones (PubMed:30468448).

Component of the parthenolide biosynthetic pathway; parthenolide and conjugates are promising anti-cancer drugs highly active against colon cancer cells (PubMed:30468448).

Hydroxylates germacrene A acid to 6-alpha-hydroxy-germacrene A acid, a precursor of sesquiterpene lactones that spontaneously undergoes a lactonization which yields costunolide (PubMed:24704560).

Sequence and Features


Assembly Compatibility:
  • 10
    COMPATIBLE WITH RFC[10]
  • 12
    COMPATIBLE WITH RFC[12]
  • 21
    COMPATIBLE WITH RFC[21]
  • 23
    COMPATIBLE WITH RFC[23]
  • 25
    COMPATIBLE WITH RFC[25]
  • 1000
    COMPATIBLE WITH RFC[1000]