Difference between revisions of "Part:BBa K4040002"
Line 2: Line 2:
 
__NOTOC__
 
__NOTOC__
 
<partinfo>BBa_K4040002 short</partinfo>
 
<partinfo>BBa_K4040002 short</partinfo>
 +
===Sequence and Features===
 +
<partinfo>BBa_K4040002 SequenceAndFeatures</partinfo>
 +
 +
===Usage and Biology===
 +
FcRγ is an adapter protein containing an immunoreceptor tyrosine-based activation motif (ITAM) that transduces activation signals from various immunoreceptors. As a component of the high-affinity immunoglobulin E (IgE) receptor, mediates allergic inflammatory signaling in mast cells. As a constitutive component of interleukin-3 receptor complex, it selectively mediates interleukin 4/IL4 production by basophils, priming T-cells toward effector T-helper 2 subset. FcRγ is associates with pattern recognition receptors CLEC4D and CLEC4E to form a functional signaling complex in myeloid cells. Binding of mycobacterial trehalose 6,6'-dimycolate (TDM) to this receptor complex leads to phosphorylation of ITAM, triggering activation of SYK, CARD9 and NF-kappa-B, consequently driving maturation of antigen-presenting cells and shaping antigen-specific priming of T-cells toward effector T-helper 1 and T-helper 17 cell subtypes. FcRγ may function cooperatively with other activating receptors. Functionally linked to integrin beta-2/ITGB2-mediated neutrophil activation. It is also involved in integrin alpha-2/ITGA2-mediated platelet activation.
 +
==Background and detail description==
 +
 +
  
−
FcRγ is an essential component of the high-affinity receptor for IgE and the low-affinity receptor for IgG. It is associated with the high-affinity receptor for IgG, the receptor for human IgA, and the TCR/CD3 complex. FcR plays an important role in the pathogenesis of antibody-induced type II hypersensitivity.
+
===Used for a CAR===
−
The usage in our project can be found in <b>CAR γ</b>(<partinfo>BBa_K4040016</partinfo>)
+
 
<!-- Add more about the biology of this part here
 
<!-- Add more about the biology of this part here
  
  
−
===Usage and Biology===
+
 
  
 
<!-- -->
 
<!-- -->
  
  
−
===Sequence and Features===
+
 
−
<partinfo>BBa_K4040002 SequenceAndFeatures</partinfo>
+
  
  

Revision as of 04:18, 2 October 2021


FcRγ Function Unit

Sequence and Features


Assembly Compatibility:
  • 10
    COMPATIBLE WITH RFC[10]
  • 12
    COMPATIBLE WITH RFC[12]
  • 21
    COMPATIBLE WITH RFC[21]
  • 23
    COMPATIBLE WITH RFC[23]
  • 25
    INCOMPATIBLE WITH RFC[25]
    Illegal NgoMIV site found at 799
    Illegal NgoMIV site found at 958
    Illegal NgoMIV site found at 1024
  • 1000
    INCOMPATIBLE WITH RFC[1000]
    Illegal BsaI.rc site found at 679
    Illegal BsaI.rc site found at 1240
    Illegal BsaI.rc site found at 1249
    Illegal SapI.rc site found at 1197

Usage and Biology

FcRγ is an adapter protein containing an immunoreceptor tyrosine-based activation motif (ITAM) that transduces activation signals from various immunoreceptors. As a component of the high-affinity immunoglobulin E (IgE) receptor, mediates allergic inflammatory signaling in mast cells. As a constitutive component of interleukin-3 receptor complex, it selectively mediates interleukin 4/IL4 production by basophils, priming T-cells toward effector T-helper 2 subset. FcRγ is associates with pattern recognition receptors CLEC4D and CLEC4E to form a functional signaling complex in myeloid cells. Binding of mycobacterial trehalose 6,6'-dimycolate (TDM) to this receptor complex leads to phosphorylation of ITAM, triggering activation of SYK, CARD9 and NF-kappa-B, consequently driving maturation of antigen-presenting cells and shaping antigen-specific priming of T-cells toward effector T-helper 1 and T-helper 17 cell subtypes. FcRγ may function cooperatively with other activating receptors. Functionally linked to integrin beta-2/ITGB2-mediated neutrophil activation. It is also involved in integrin alpha-2/ITGA2-mediated platelet activation.

Background and detail description

Used for a CAR