Difference between revisions of "Part:BBa I712020"
 
(2 intermediate revisions by the same user not shown)
Line 16: Line 16:
 
Summary: Added information collated from existing scientific studies
 
Summary: Added information collated from existing scientific studies
  
−
Part is involved in the activation cascade of caspases contributing to apoptosis.
 
  
 +
Part is involved in the activation cascade of caspases contributing to apoptosis.
 
At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond  
 
At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond  
 +
Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9.
 +
The part is also involved in the cleavage of Huntingtin (HTT gene). <ref>“CASP3 - Caspase-3 Precursor - Homo Sapiens (Human) - CASP3 Gene & Protein.” 2021. Uniprot.org. 2021. https://www.uniprot.org/uniprot/P42574.
 +
 +
‌</ref>
 +
  
−
Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9
+
===Activity Regulation===
  
−
The part is also involved in the cleavage of Huntingtin (HTT gene).
+
Part is inhibited via isatin sulfonamides
  
  

Latest revision as of 17:40, 1 October 2021


Homo sapiens caspase 3

Homo sapiens caspase 3, apoptosis-related cysteine peptidase (transcript variant beta).

Information contributed by City of London UK (2021)

Part information is collated here to help future users of the BioBrick registry.

Metadata:

Group: City of London UK 2021

Author: Julian Chen

Summary: Added information collated from existing scientific studies


Part is involved in the activation cascade of caspases contributing to apoptosis. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. The part is also involved in the cleavage of Huntingtin (HTT gene). [1]


Activity Regulation

Part is inhibited via isatin sulfonamides



Sequence and Features


Assembly Compatibility:
  • 10
    COMPATIBLE WITH RFC[10]
  • 12
    COMPATIBLE WITH RFC[12]
  • 21
    COMPATIBLE WITH RFC[21]
  • 23
    COMPATIBLE WITH RFC[23]
  • 25
    COMPATIBLE WITH RFC[25]
  • 1000
    COMPATIBLE WITH RFC[1000]


  1. ↑ “CASP3 - Caspase-3 Precursor - Homo Sapiens (Human) - CASP3 Gene & Protein.” 2021. Uniprot.org. 2021. https://www.uniprot.org/uniprot/P42574. ‌