Difference between revisions of "Part:BBa K4040003"
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<partinfo>BBa_K4040003 short</partinfo>
 
<partinfo>BBa_K4040003 short</partinfo>
  
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<h3><b>The structure and function of CAR &#950;</b></h3>
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CD3 zeta chain is a part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways.
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CAR &#950; is another CAR aimed to increase the phagocytosis of the macrophages. And the structure is also similar to the other three CARs, with the difference in the intracellular domain which is replaced by CD &#950; subunit of the T cell receptor.
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<h3><b>The mechanism of CAR &#950;</b></h3>
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The main function domain of the CAR &#950; is the cytosolic Immunoreceptor Tyrosine-based Activation Motifs (ITAMs) as mentioned before. When the ligands matches its receptor, the Src family kinases will consequently be phosphorylated and thus activating the cytosolic Immunoreceptor Tyrosine-based Activation Motifs (ITAMs). The further signal pathway is the same as mentioned in CAR-MEGF10.
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===References===
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[1]The CD4 and CD8 antigens are coupled to a protein-tyrosine kinase (p56lck) that phosphorylates the CD3 complex.Barber E.K., Dasgupta J.D., Schlossman S.F., Trevillyan J.M., Rudd C.E.
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[2]Sequential interactions of the TCR with two distinct cytoplasmic tyrosine kinases.Iwashima M., Irving B.A., van Oers N.S., Chan A.C., Weiss A.
 
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===Usage and Biology===
 
===Usage and Biology===
  
 
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<span class='h3bb'>Sequence and Features</span>
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===Sequence and Features===
 
<partinfo>BBa_K4040003 SequenceAndFeatures</partinfo>
 
<partinfo>BBa_K4040003 SequenceAndFeatures</partinfo>
  

Revision as of 00:22, 15 September 2021


Intracellular Domain of CD3 zeta chain

CD3 zeta chain is a part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways.

References

[1]The CD4 and CD8 antigens are coupled to a protein-tyrosine kinase (p56lck) that phosphorylates the CD3 complex.Barber E.K., Dasgupta J.D., Schlossman S.F., Trevillyan J.M., Rudd C.E.

[2]Sequential interactions of the TCR with two distinct cytoplasmic tyrosine kinases.Iwashima M., Irving B.A., van Oers N.S., Chan A.C., Weiss A.

Sequence and Features


Assembly Compatibility:
  • 10
    COMPATIBLE WITH RFC[10]
  • 12
    COMPATIBLE WITH RFC[12]
  • 21
    COMPATIBLE WITH RFC[21]
  • 23
    COMPATIBLE WITH RFC[23]
  • 25
    COMPATIBLE WITH RFC[25]
  • 1000
    COMPATIBLE WITH RFC[1000]