Difference between revisions of "Part:BBa K1500994"
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===Information contributed by City of London UK (2021)=== | ===Information contributed by City of London UK (2021)=== | ||
Part information is collated here to help future users of the BioBrick registry. | Part information is collated here to help future users of the BioBrick registry. | ||
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| + | Metadata: | ||
| + | *'''Group:''' City of London UK 2021 | ||
| + | *'''Author:''' Lucas Ng | ||
| + | *'''Summary:''' Added information collated from existing scientific studies | ||
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dam causes DNA methylation within the sequence GATC, preventing cleavage by the MboI restriction endonuclease [https://pubmed.ncbi.nlm.nih.gov/368070] | dam causes DNA methylation within the sequence GATC, preventing cleavage by the MboI restriction endonuclease [https://pubmed.ncbi.nlm.nih.gov/368070] | ||
Revision as of 10:57, 26 July 2021
Dam
Involved in methylating DNA, overexpression causes 6.4 * 10^-4 /// 6.4 * 10^4 mutation rate increase, mostly catalyzing transversions.
Information contributed by City of London UK (2021)
Part information is collated here to help future users of the BioBrick registry.
Metadata:
- Group: City of London UK 2021
- Author: Lucas Ng
- Summary: Added information collated from existing scientific studies
dam causes DNA methylation within the sequence GATC, preventing cleavage by the MboI restriction endonuclease [1]
It is likely to act in postreplication mismatch repair [2] rather than as a member of a restriction modification system, despite sharing sequence specificity with several type II restriction methylases and endonucleases as part of the N(4)/N(6)-methyltransferase family [3]
Furthermore, it may also be involved in DNA replication [4]
Reaction
a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an N6-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-homocysteine