Difference between revisions of "Part:BBa K3450020"
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+ | __NOTOC__ | ||
+ | <partinfo>BBa_K3450020 short</partinfo> | ||
+ | Exendin-4, the dipeptidyl peptidase resistant analogue of GLP-1 was discovered in the venom of a poisonous lizard known as Gila monster (Heloderma suspectum). It has a half-life of about 26 minutes in humans after intravenous infusion which is significantly higher than the half-life of active GLP-1 molecule (1–2 minutes) in humans. [1] | ||
+ | |||
+ | Reference | ||
+ | |||
+ | [1] Simonsen, L., Holst, J.J. & Deacon, C.F. Exendin-4, but not glucagon-like peptide-1, is cleared exclusively by glomerular filtration in anaesthetised pigs. Diabetologia 49, 706–712 (2006). https://doi.org/10.1007/s00125-005-0128-9 | ||
+ | |||
+ | <!-- Add more about the biology of this part here | ||
+ | ===Usage and Biology=== | ||
+ | |||
+ | <!-- --> | ||
+ | <span class='h3bb'>Sequence and Features</span> | ||
+ | <partinfo>BBa_K3450020 SequenceAndFeatures</partinfo> | ||
+ | |||
+ | |||
+ | <!-- Uncomment this to enable Functional Parameter display | ||
+ | ===Functional Parameters=== | ||
+ | <partinfo>BBa_K3450020 parameters</partinfo> | ||
+ | <!-- --> |
Latest revision as of 16:37, 26 October 2020
Exendin-4
Exendin-4, the dipeptidyl peptidase resistant analogue of GLP-1 was discovered in the venom of a poisonous lizard known as Gila monster (Heloderma suspectum). It has a half-life of about 26 minutes in humans after intravenous infusion which is significantly higher than the half-life of active GLP-1 molecule (1–2 minutes) in humans. [1]
Reference
[1] Simonsen, L., Holst, J.J. & Deacon, C.F. Exendin-4, but not glucagon-like peptide-1, is cleared exclusively by glomerular filtration in anaesthetised pigs. Diabetologia 49, 706–712 (2006). https://doi.org/10.1007/s00125-005-0128-9
Sequence and Features
Assembly Compatibility:
- 10COMPATIBLE WITH RFC[10]
- 12COMPATIBLE WITH RFC[12]
- 21COMPATIBLE WITH RFC[21]
- 23COMPATIBLE WITH RFC[23]
- 25COMPATIBLE WITH RFC[25]
- 1000COMPATIBLE WITH RFC[1000]