Difference between revisions of "Part:BBa K3450001"

 
 
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<partinfo>BBa_K3450001 short</partinfo>
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β-catenin is a human transcription factor responsible for effecting pro-survival and pro-proliferative signals downstream of the Wnt signalling cascade, through its Wnt-dependent protection from the cell’s proteasomal machinery. This feature can be exploited to ensure the cell-specific retention of proteins it is fused to, since protein fusions containing β-catenin are only stable in cells that receive and transduce Wnt signals, such as actively cycling stem cell niches.
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It is to be noted, however, that the specificity of its retention can be hindered by N-terminal fusions, since its own N-terminus is responsible for interactions with the factors that degrade it.
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===Usage and Biology===
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<span class='h3bb'>Sequence and Features</span>
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<partinfo>BBa_K3450001 SequenceAndFeatures</partinfo>
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===Functional Parameters===
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<partinfo>BBa_K3450001 parameters</partinfo>
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Latest revision as of 15:14, 26 October 2020


Beta Catenin: Transcription factor and an effector of the Wnt signalling pathway.


β-catenin is a human transcription factor responsible for effecting pro-survival and pro-proliferative signals downstream of the Wnt signalling cascade, through its Wnt-dependent protection from the cell’s proteasomal machinery. This feature can be exploited to ensure the cell-specific retention of proteins it is fused to, since protein fusions containing β-catenin are only stable in cells that receive and transduce Wnt signals, such as actively cycling stem cell niches.

It is to be noted, however, that the specificity of its retention can be hindered by N-terminal fusions, since its own N-terminus is responsible for interactions with the factors that degrade it.

Sequence and Features


Assembly Compatibility:
  • 10
    COMPATIBLE WITH RFC[10]
  • 12
    COMPATIBLE WITH RFC[12]
  • 21
    INCOMPATIBLE WITH RFC[21]
    Illegal BamHI site found at 2193
  • 23
    COMPATIBLE WITH RFC[23]
  • 25
    INCOMPATIBLE WITH RFC[25]
    Illegal NgoMIV site found at 643
    Illegal NgoMIV site found at 1062
    Illegal NgoMIV site found at 1386
    Illegal AgeI site found at 1720
  • 1000
    COMPATIBLE WITH RFC[1000]