Difference between revisions of "Part:BBa K3117039"
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<partinfo>BBa_K3117039 short</partinfo>
 
<partinfo>BBa_K3117039 short</partinfo>
  
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part BBa_K3117039 is the constant part of the light chain within an antibody. Together with the single chain variable fragment, the kappa-light chain forms a fab fragment.
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===Usage and Biology===
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Part BBa_K3117039 is the constant part of the light chain within an antibody. Together with the single chain variable fragment, the kappa-light chain forms the variable light chain of an antibody. Additionally, the kappa-light chain binds to the constant region 1 (<partinfo>BBa_K3117040</partinfo>) of an antibody via disulfid bonds.
  
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==MIT_MAHE 2020==
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'''Summary'''
  
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===Usage and Biology===
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Kappa light chain is the constant part of the light chain within an antibody. Together with the single chain variable fragment, the kappa-light chain forms the variable light chain of an antibody. Additionally, the kappa-light chain binds to the constant region 1 of an antibody via disulfide bonds.
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==References==
  
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According to the creation of bispecific antibodies, different fabs can be linked.
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1. Vincent Rajkumar S. (2014). Multiple myeloma: 2014 Update on diagnosis, risk-stratification, and management. American journal of hematology, 89(10), 999–1009. https://doi.org/10.1002/ajh.23810
  
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2. Rajkumar, S. V., Dimopoulos, M. A., Palumbo, A., Blade, J., Merlini, G., Mateos, M. V., Kumar, S., Hillengass, J., Kastritis, E., Richardson, P., Landgren, O., Paiva, B., Dispenzieri, A., Weiss, B., LeLeu, X., Zweegman, S., Lonial, S., Rosinol, L., Zamagni, E., Jagannath, S., … Miguel, J. F. (2014). International Myeloma Working Group updated criteria for the diagnosis of multiple myeloma. The Lancet. Oncology, 15(12), e538–e548. https://doi.org/10.1016/S1470-2045(14)70442-5
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<span class='h3bb'>Sequence and Features</span>
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<partinfo>BBa_K3117039 SequenceAndFeatures</partinfo>
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3. Chen, J., Fang, M., Zhao, Y. P., Yi, C. H., Ji, J., Cheng, C., Wang, M. M., Gu, X., Sun, Q. S., Chen, X. L., & Gao, C. F. (2015). Serum N-Glycans: A New Diagnostic Biomarker for Light Chain Multiple Myeloma. PloS one, 10(6), e0127022. https://doi.org/10.1371/journal.pone.0127022
  
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4. Siegel, R., Ma, J., Zou, Z., & Jemal, A. (2014). Cancer statistics, 2014. CA: a cancer journal for clinicians, 64(1), 9–29. https://doi.org/10.3322/caac.21208 "
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===Functional Parameters===
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<partinfo>BBa_K3117039 parameters</partinfo>
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Latest revision as of 18:15, 23 October 2020


kappa light chain

Usage and Biology

Part BBa_K3117039 is the constant part of the light chain within an antibody. Together with the single chain variable fragment, the kappa-light chain forms the variable light chain of an antibody. Additionally, the kappa-light chain binds to the constant region 1 (BBa_K3117040) of an antibody via disulfid bonds.

MIT_MAHE 2020

Summary

Kappa light chain is the constant part of the light chain within an antibody. Together with the single chain variable fragment, the kappa-light chain forms the variable light chain of an antibody. Additionally, the kappa-light chain binds to the constant region 1 of an antibody via disulfide bonds.

References

1. Vincent Rajkumar S. (2014). Multiple myeloma: 2014 Update on diagnosis, risk-stratification, and management. American journal of hematology, 89(10), 999–1009. https://doi.org/10.1002/ajh.23810

2. Rajkumar, S. V., Dimopoulos, M. A., Palumbo, A., Blade, J., Merlini, G., Mateos, M. V., Kumar, S., Hillengass, J., Kastritis, E., Richardson, P., Landgren, O., Paiva, B., Dispenzieri, A., Weiss, B., LeLeu, X., Zweegman, S., Lonial, S., Rosinol, L., Zamagni, E., Jagannath, S., … Miguel, J. F. (2014). International Myeloma Working Group updated criteria for the diagnosis of multiple myeloma. The Lancet. Oncology, 15(12), e538–e548. https://doi.org/10.1016/S1470-2045(14)70442-5

3. Chen, J., Fang, M., Zhao, Y. P., Yi, C. H., Ji, J., Cheng, C., Wang, M. M., Gu, X., Sun, Q. S., Chen, X. L., & Gao, C. F. (2015). Serum N-Glycans: A New Diagnostic Biomarker for Light Chain Multiple Myeloma. PloS one, 10(6), e0127022. https://doi.org/10.1371/journal.pone.0127022

4. Siegel, R., Ma, J., Zou, Z., & Jemal, A. (2014). Cancer statistics, 2014. CA: a cancer journal for clinicians, 64(1), 9–29. https://doi.org/10.3322/caac.21208 "