Difference between revisions of "Part:BBa K3582301"

Revision as of 15:42, 22 October 2020

Basigin protein

Basigin (BSG) is a member of the Ig superfamily and is important in numerous physiological and pathological phenomena. It is a highly glycosylated transmembrane protein and can recognize molecules both in the same membrane (cis-recognition) as well as those located extracellularly[1].

Basigin is known to bind to MonoCarboxylate Transporter(MCTs) which catalyse the transport of substituted short-chain fatty acids across the plasma membrane[2]. Basigin acts as a chaperone, important for the membrane translocation of MCTs. By associating with MCTs, Basigin plays an important role in energy metabolism. The tight association between Basigin and MCTs is consistent with the high level of expression of BSG in metabolically active cells, such as tumour cells and activated lymphocytes[3]

CD98, CD43, MCT4 and galectin-3 are important proteins that mediate binding between Basigin and integrins. BSG directly binds to CD98, which can covalently bind to amino acid transporters and hence can associate with integrins. Therefore, BSG can interact with integrins through CD98[4]

Basigin is a major signalling receptor for cyclophilin A (and cyclophilin B, a related molecule) which when secreted exhibits chemotactic activity for neutrophils, eosinophils and T cells[5][6]

Sequence and Features